Activating Compound | Comment | Organism | Structure |
---|---|---|---|
angiotensin II | - |
Homo sapiens |
Cloned (Comment) | Organism |
---|---|
overexpression of VEGFR-1 tyrosine kinase in Tn5 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-(N-3-carboxyphenylaminomethyl)-phenylboronic acid | inhibition of EGFR tyrosine kinase | Homo sapiens | |
4-(2',5'-dihydroxybenzylamino)phenylboronic acid | inhibition of EGFR tyrosine kinase | Homo sapiens | |
4-(N-3-carboxyphenylaminomethyl)-phenylboronic acid | inhibition of EGFR tyrosine kinase | Homo sapiens | |
4-methoxy-3-((2'-methoxybenzylamino)methyl)phenylboronic acid | inhibition of EGFR tyrosine kinase | Homo sapiens | |
5-(4-(dihydroxyboranyl)benzylamino)-2-hydroxybenzoic acid | inhibition of EGFR tyrosine kinase | Homo sapiens | |
active pharmacophore 1 | derivative of lavendustin A, inhibition of EGFR tyrosine kinase | Homo sapiens | |
additional information | inhibitory potency of diverse aminoboronic acids, e.g. no inhibition of EGFR tyrosine kinase by 3-(2,5-dihydroxybenzylamino)phenylboronic acid, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | EGFR tyrosine kinase | Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens | |
Mn2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [endothelial growth-factor]-L-tyrosine | Homo sapiens | EGFR tyrosine kinase | ADP + [endothelial growth-factor]-L-tyrosine phosphate | - |
? | |
ATP + [vascular endothelial growth-factor-1]-L-tyrosine | Homo sapiens | VEGFR-1 tyrosine kinase | ADP + [vascular endothelial growth-factor-1]-L-tyrosine phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-431 cell | EGFR tyrosine kinase | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [endothelial growth-factor]-L-tyrosine | EGFR tyrosine kinase | Homo sapiens | ADP + [endothelial growth-factor]-L-tyrosine phosphate | - |
? | |
ATP + [vascular endothelial growth-factor-1]-L-tyrosine | VEGFR-1 tyrosine kinase | Homo sapiens | ADP + [vascular endothelial growth-factor-1]-L-tyrosine phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
EGFR tyrosine kinase | - |
Homo sapiens |
epidermal growth-factor receptor tyrosine kinase | - |
Homo sapiens |
vascular endothelial growth-factor receptor-1 tyrosine kinase | - |
Homo sapiens |
VEGFR-1 tyrosine kinase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |