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Literature summary for 2.7.10.1 extracted from

  • Asano, T.; Nakamura, H.; Uehara, Y.; Yamamoto, Y.
    Design, synthesis, and biological evaluation of aminoboronic acids as growth-factor receptor inhibitors of EGFR and VEGFR-1 tyrosine kinases (2004), ChemBioChem, 5, 483-490.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
angiotensin II
-
Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of VEGFR-1 tyrosine kinase in Tn5 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-(N-3-carboxyphenylaminomethyl)-phenylboronic acid inhibition of EGFR tyrosine kinase Homo sapiens
4-(2',5'-dihydroxybenzylamino)phenylboronic acid inhibition of EGFR tyrosine kinase Homo sapiens
4-(N-3-carboxyphenylaminomethyl)-phenylboronic acid inhibition of EGFR tyrosine kinase Homo sapiens
4-methoxy-3-((2'-methoxybenzylamino)methyl)phenylboronic acid inhibition of EGFR tyrosine kinase Homo sapiens
5-(4-(dihydroxyboranyl)benzylamino)-2-hydroxybenzoic acid inhibition of EGFR tyrosine kinase Homo sapiens
active pharmacophore 1 derivative of lavendustin A, inhibition of EGFR tyrosine kinase Homo sapiens
additional information inhibitory potency of diverse aminoboronic acids, e.g. no inhibition of EGFR tyrosine kinase by 3-(2,5-dihydroxybenzylamino)phenylboronic acid, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane EGFR tyrosine kinase Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens
Mn2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [endothelial growth-factor]-L-tyrosine Homo sapiens EGFR tyrosine kinase ADP + [endothelial growth-factor]-L-tyrosine phosphate
-
?
ATP + [vascular endothelial growth-factor-1]-L-tyrosine Homo sapiens VEGFR-1 tyrosine kinase ADP + [vascular endothelial growth-factor-1]-L-tyrosine phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-431 cell EGFR tyrosine kinase Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [endothelial growth-factor]-L-tyrosine EGFR tyrosine kinase Homo sapiens ADP + [endothelial growth-factor]-L-tyrosine phosphate
-
?
ATP + [vascular endothelial growth-factor-1]-L-tyrosine VEGFR-1 tyrosine kinase Homo sapiens ADP + [vascular endothelial growth-factor-1]-L-tyrosine phosphate
-
?

Synonyms

Synonyms Comment Organism
EGFR tyrosine kinase
-
Homo sapiens
epidermal growth-factor receptor tyrosine kinase
-
Homo sapiens
vascular endothelial growth-factor receptor-1 tyrosine kinase
-
Homo sapiens
VEGFR-1 tyrosine kinase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens