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Literature summary for 2.7.10.1 extracted from

  • Ruschel, A.; Ullrich, A.
    Protein tyrosine kinase Syk modulates EGFR signalling in human mammary epithelial cells (2004), Cell. Signal., 16, 1249-1261.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information downregulation of endogenous Syk non-receptor tyrosine protein kinase expression in mammary endothelial cells enhances the ligand-induced activity of the epidermal growth factor receptor, but not of closely related human epidermal growth factor receptors HER2 and HER3, autophosphorylation inhibits EGFR, which is activated by Syk Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
180000
-
x * 180000, EGFR, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a [protein]-L-tyrosine Homo sapiens phosphorylation of downstream signalling proteins ADP + a [protein]-L-tyrosine phosphate
-
?
additional information Homo sapiens downregulation of endogenous Syk non-receptor tyrosine protein kinase expression in mammary endothelial cells enhances the ligand-induced activity of the epidermal growth factor receptor, but not of closely related human epidermal growth factor receptors HER2 and HER3, EGFR has a regulatory feedback effect on Syk, enzyme deregulation is associated with pathophysiological disorders such as cancer, regulation in vivo overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein EGFR performs autophosphorylation, which is activated by non-receptor protein tyrosine kinase Syk Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
breast
-
Homo sapiens
-
epithelial cell mammary gland Homo sapiens
-
epithelium
-
Homo sapiens
-
mammary gland epithelial cells Homo sapiens
-
MCF-10A cell mammary epithelial cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a [protein]-L-tyrosine
-
Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
?
ATP + a [protein]-L-tyrosine phosphorylation of downstream signalling proteins Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
?
additional information downregulation of endogenous Syk non-receptor tyrosine protein kinase expression in mammary endothelial cells enhances the ligand-induced activity of the epidermal growth factor receptor, but not of closely related human epidermal growth factor receptors HER2 and HER3, EGFR has a regulatory feedback effect on Syk, enzyme deregulation is associated with pathophysiological disorders such as cancer, regulation in vivo overview Homo sapiens ?
-
?
additional information EGFR performs autophosphorylation Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
? x * 180000, EGFR, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
Egfr
-
Homo sapiens
epidermal growth factor receptor
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens