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Literature summary for 2.7.10.1 extracted from

  • Holland, W.; Morrison, T.; Chang, Y.; Wiernsperger, N.; Stith, B.J.
    Metformin (Glucophage) inhibits tyrosine phosphatase activity to stimulate the insulin receptor tyrosine kinase (2004), Biochem. Pharmacol., 67, 2081-2091.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
metformin i.e. N,N-dimethylbiguanide or N,N-dimethylimidodicarbonimidic diamide, activates the insulin receptor tyrosine kinase by phosphorylation at Tyr1150 and Tyr1151, and indirectly via inhibition of protein tyrosine phosphatase 1B, metformin does not alter the order of substrate phosphorylation by the insulin receptor tyrosine kinase Homo sapiens
metformin i.e. N,N-dimethylbiguanide or N,N-dimethylimidodicarbonimidic diamide, activates the insulin receptor tyrosine kinase by phosphorylation, and indirectly via inhibition of protein tyrosine phosphatase, metformin does not alter the order of substrate phosphorylation by the insulin receptor tyrosine kinase Xenopus laevis
additional information activation of the insulin receptor by phosphorylation via its tyrosine kinase activity Homo sapiens
additional information activation of the insulin receptor by phosphorylation via its tyrosine kinase activity Xenopus laevis

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibition of the insulin receptor tyrosine kinase and insulin action by dephosphorylation at Tyr1150 and Tyr1151 via protein tyrosine phosphatase 1B Homo sapiens
additional information inhibition of the insulin receptor tyrosine kinase and insulin action by dephosphorylation Xenopus laevis

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-
membrane
-
Xenopus laevis 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens
Mn2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a [protein]-L-tyrosine Homo sapiens
-
ADP + a [protein]-L-tyrosine phosphate
-
?
ATP + a [protein]-L-tyrosine Xenopus laevis
-
ADP + a [protein]-L-tyrosine phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Xenopus laevis
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein autophosphorylation of the insulin receptor via its protein tyrosine kinase activity, metformin activates the insulin receptor tyrosine kinase by phosphorylation at Tyr1150 and Tyr1151 Homo sapiens
phosphoprotein autophosphorylation of the insulin receptor via its protein tyrosine kinase activity, metformin activates the insulin receptor tyrosine kinase by phosphorylation at Tyr1150 and Tyr1151 Xenopus laevis

Source Tissue

Source Tissue Comment Organism Textmining
oocyte stage IV Xenopus laevis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a [protein]-L-tyrosine
-
Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
?
ATP + a [protein]-L-tyrosine
-
Xenopus laevis ADP + a [protein]-L-tyrosine phosphate
-
?
ATP + insulin receptor substrate 1-L-tyrosine peptide derived from the regulatory domain of insulin receptor Homo sapiens ADP + insulin receptor substrate 1-L-tyrosine phosphate
-
?
additional information autophosphorylation of the insulin receptor via its protein tyrosine kinase activity, regulation mechanism Homo sapiens ?
-
?
additional information autophosphorylation of the insulin receptor via its protein tyrosine kinase activity, regulation mechanism Xenopus laevis ?
-
?

Synonyms

Synonyms Comment Organism
insulin receptor kinase
-
Homo sapiens
insulin receptor kinase
-
Xenopus laevis
insulin receptor tyrosine kinase
-
Homo sapiens
insulin receptor tyrosine kinase
-
Xenopus laevis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens