Activating Compound | Comment | Organism | Structure |
---|---|---|---|
metformin | i.e. N,N-dimethylbiguanide or N,N-dimethylimidodicarbonimidic diamide, activates the insulin receptor tyrosine kinase by phosphorylation at Tyr1150 and Tyr1151, and indirectly via inhibition of protein tyrosine phosphatase 1B, metformin does not alter the order of substrate phosphorylation by the insulin receptor tyrosine kinase | Homo sapiens | |
metformin | i.e. N,N-dimethylbiguanide or N,N-dimethylimidodicarbonimidic diamide, activates the insulin receptor tyrosine kinase by phosphorylation, and indirectly via inhibition of protein tyrosine phosphatase, metformin does not alter the order of substrate phosphorylation by the insulin receptor tyrosine kinase | Xenopus laevis | |
additional information | activation of the insulin receptor by phosphorylation via its tyrosine kinase activity | Homo sapiens | |
additional information | activation of the insulin receptor by phosphorylation via its tyrosine kinase activity | Xenopus laevis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | inhibition of the insulin receptor tyrosine kinase and insulin action by dephosphorylation at Tyr1150 and Tyr1151 via protein tyrosine phosphatase 1B | Homo sapiens | |
additional information | inhibition of the insulin receptor tyrosine kinase and insulin action by dephosphorylation | Xenopus laevis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
membrane | - |
Xenopus laevis | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens | |
Mn2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [protein]-L-tyrosine | Homo sapiens | - |
ADP + a [protein]-L-tyrosine phosphate | - |
? | |
ATP + a [protein]-L-tyrosine | Xenopus laevis | - |
ADP + a [protein]-L-tyrosine phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Xenopus laevis | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | autophosphorylation of the insulin receptor via its protein tyrosine kinase activity, metformin activates the insulin receptor tyrosine kinase by phosphorylation at Tyr1150 and Tyr1151 | Homo sapiens |
phosphoprotein | autophosphorylation of the insulin receptor via its protein tyrosine kinase activity, metformin activates the insulin receptor tyrosine kinase by phosphorylation at Tyr1150 and Tyr1151 | Xenopus laevis |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
oocyte | stage IV | Xenopus laevis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [protein]-L-tyrosine | - |
Homo sapiens | ADP + a [protein]-L-tyrosine phosphate | - |
? | |
ATP + a [protein]-L-tyrosine | - |
Xenopus laevis | ADP + a [protein]-L-tyrosine phosphate | - |
? | |
ATP + insulin receptor substrate 1-L-tyrosine | peptide derived from the regulatory domain of insulin receptor | Homo sapiens | ADP + insulin receptor substrate 1-L-tyrosine phosphate | - |
? | |
additional information | autophosphorylation of the insulin receptor via its protein tyrosine kinase activity, regulation mechanism | Homo sapiens | ? | - |
? | |
additional information | autophosphorylation of the insulin receptor via its protein tyrosine kinase activity, regulation mechanism | Xenopus laevis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
insulin receptor kinase | - |
Homo sapiens |
insulin receptor kinase | - |
Xenopus laevis |
insulin receptor tyrosine kinase | - |
Homo sapiens |
insulin receptor tyrosine kinase | - |
Xenopus laevis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |