Activating Compound | Comment | Organism | Structure |
---|---|---|---|
hydrogen peroxide | activates the autophosphorylation and protein tyrosine phosphorylation activities of the insulin receptor, and thus the insulin receptor signaling pathway, overview | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
overexpression of wild-type enzyme CHO-IR and K1018A mutant enzyme CHO-1018 in CHO cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
K1018A | construction of a defective-enzyme mutant CHO-1018 cell line which shows a loss in ATP-binding activity and thus in PTK function | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | insulin- or H2O2-induced activation by autophosphorylation of the insulin receptor initiates the IR signaling pathway which includes phosphorylation of extracellular signal-regulated kinases 1 and 2, i.e. ERK1 and ERK2, protein kinase B, and glycogen synthase kinase 3-beta | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | activation via insulin-induced autophosphorylation, can also be induced by H2O2 | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | insulin- or H2O2-induced activation by autophosphorylation of the insulin receptor initiates the IR signaling pathway which includes phosphorylation of extracellular signal-regulated kinases 1 and 2, i.e. ERK1 and ERK2, protein kinase B, and glycogen synthase kinase 3-beta | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the tyrosine kinase activity is located on the beta-subunit of the insulin receptor | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
insulin receptor protein tyrosine kinase | - |
Homo sapiens |
insulin receptor-beta subunit | - |
Homo sapiens |
iR-beta subunit | - |
Homo sapiens |
IR-PTK | - |
Homo sapiens |
non-receptor protein tyrosine kinase | - |
Homo sapiens |