Literature summary for 2.7.10.1 extracted from

Peters, K.G.; Marie, J.; Wilson, E.; Ives, H.E.; Escobedo, J.; Del Rosario, M.; Mirda, D.; Williams, L.T.
Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis (1992), Nature, 358, 678-681.

Search for more literature for 2.7.10.1

Protein Variants

Protein Variants	Comment	Organism
Y766F	fibroblast growth factor receptor with the single point mutation fails to associate with PLC gamma in response to FGF. The mutant receptor also fails to mediate PtdIns hydrolysis and Ca2+ mobilization after FGF stimulation. However, the mutant receptor phosphorylats itself and several other cellular proteins, and it mediats mitogenesis in response to FGF	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P11362	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + phospholipase C gamma	-	Homo sapiens	ADP + phosphorylated phospholipase C gamma	-	?

Synonyms

Synonyms	Comment	Organism
basic fibroblast growth factor receptor 1	-	Homo sapiens

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Release 2023.1 (January 2023)