Literature summary for 2.7.10.1 extracted from

Mohammadi, M.; McMahon, G.; Sun, L.; Tang, C.; Hirth, P.; Yeh, B.K.; Hubbard, S.R.; Schlessinger, J.
Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors (1997), Science, 276, 955-960.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
crystal structures of the tyrosine kinase domain of FGFR1 in complex with two inhibitors based on an oxindole core, indolinones	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	inhibitors based on an oxindole core, indolinones. Oxindole occupies the site in which theATP binds, whereas the moieties that extend from the oxindole contact residues in the hinge region between the two kinase lobes. The more specific inhibitor of FGFR1 induces a conformational change in the nucleotide-binding loop	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P11362	-	-

Synonyms

Synonyms	Comment	Organism
basic fibroblast growth factor receptor 1	-	Homo sapiens

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Release 2023.1 (January 2023)