Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of enzyme-deficient sphk1-/- mice, platelets from sphk1-/- mice do not show spontaneous or activation-dependent formation of platelet-leukocyte aggregates and a significantly increased activation-dependent ATP release and in vitro thrombus formation compared with the wild-type | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8CI15 | - |
- |
Mus musculus C57BL/6 | Q8CI15 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
sphingosine kinase | - |
Mus musculus |
sphingosine kinase 1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | activation-dependent increase of intracellular Ca2+ concentration, degranulation (release of alpha and dense granules), integrin alphaIIbbeta3 activation, and aggregation are all significantly increased in enzyme-deficient sphk1-/- platelets compared with wild-type sphk1+/+ platelets. While platelet adhesion and thrombus formation under arterial shear rates are significantly augmented in Sphk1-deficient platelets, bleeding time and blood count are unaffected in sphk1-/- mice | Mus musculus |
physiological function | sphingosine kinase 1 is a powerful negative regulator of platelet function counteracting degranulation, aggregation, and thrombus formation. In mast cells, intracellular Ca2+ is rapidly and transiently increased by spingosine kinase 1. Sphingosine 1-phosphate mobilizes intracellular Ca2+ in mast cells in an inositol triphosphate-dependent manner. In other cell types, sphingosine kinases regulate intracellular Ca2+ by influencing voltage-gated Ca2+ channels or by activating the store-operated calcium entry. Sphingosine kinases and sphingosine 1-phosphate further regulate platelet formation by megakaryopoiesis. They are effective by upregulating Src family kinases in megakaryocytes. Megakyocytes express the S1P multifunctional receptor S1pr1, and S1P signaling is an important prerequisite for proper thrombopoesis | Mus musculus |