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Literature summary for 2.7.1.91 extracted from

  • Muenzer, P.; Schmid, E.; Walker, B.; Fotinos, A.; Chatterjee, M.; Rath, D.; Vogel, S.; Hoffmann, S.M.; Metzger, K.; Seizer, P.; Geisler, T.; Gawaz, M.; Borst, O.; Lang, F.
    Sphingosine kinase 1 (Sphk1) negatively regulates platelet activation and thrombus formation (2014), Am. J. Physiol. Cell Physiol., 307, C920-C927.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information generation of enzyme-deficient sphk1-/- mice, platelets from sphk1-/- mice do not show spontaneous or activation-dependent formation of platelet-leukocyte aggregates and a significantly increased activation-dependent ATP release and in vitro thrombus formation compared with the wild-type Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q8CI15
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Mus musculus C57BL/6 Q8CI15
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-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
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 Mus musculus
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Synonyms

Synonyms Comment Organism
sphingosine kinase
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 Mus musculus
sphingosine kinase 1
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 Mus musculus

General Information

General Information Comment Organism
malfunction activation-dependent increase of intracellular Ca2+ concentration, degranulation (release of alpha and dense granules), integrin alphaIIbbeta3 activation, and aggregation are all significantly increased in enzyme-deficient sphk1-/- platelets compared with wild-type sphk1+/+ platelets. While platelet adhesion and thrombus formation under arterial shear rates are significantly augmented in Sphk1-deficient platelets, bleeding time and blood count are unaffected in sphk1-/- mice Mus musculus
physiological function sphingosine kinase 1 is a powerful negative regulator of platelet function counteracting degranulation, aggregation, and thrombus formation. In mast cells, intracellular Ca2+ is rapidly and transiently increased by spingosine kinase 1. Sphingosine 1-phosphate mobilizes intracellular Ca2+ in mast cells in an inositol triphosphate-dependent manner. In other cell types, sphingosine kinases regulate intracellular Ca2+ by influencing voltage-gated Ca2+ channels or by activating the store-operated calcium entry. Sphingosine kinases and sphingosine 1-phosphate further regulate platelet formation by megakaryopoiesis. They are effective by upregulating Src family kinases in megakaryocytes. Megakyocytes express the S1P multifunctional receptor S1pr1, and S1P signaling is an important prerequisite for proper thrombopoesis Mus musculus