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Literature summary for 2.7.1.91 extracted from

  • Maceyka, M.; Alvarez, S.E.; Milstien, S.; Spiegel, S.
    Filamin A links sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 at lamellipodia to orchestrate cell migration (2008), Mol. Cell. Biol., 28, 5687-5697.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.91

Activating Compound

Activating Compound Comment Organism Structure
heregulin heregulin stimulates SphK1 activity only in filamin A-expressing A7 melanoma cells but not in filamin A-deficient cells and induces its translocation and colocalization with filamin A at lamellipodia. SphK1 is required for heregulin-induced migration, lamellipodia formation, activation of PAK1, and subsequent filamin A phosphorylation. Sphingosine 1-phosphate directly stimulates PAK1 kinase. Heregulin also induces colocalization of S1P1, the promotility sphingosine 1-phosphate receptor, but not S1P2, with SphK1 and filamin A at membrane ruffles Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK-293 cell Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A7 cell
-
 Homo sapiens
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melanoma cell line
-
 Homo sapiens
-

General Information

General Information Comment Organism
physiological function filamin A links SphK1 and S1P1 receptor to locally influence the dynamics of actin cytoskeletal structures by orchestrating the concerted actions of of SphK1, FLNa, and PAK1, each of which requires and/or regulates the actions of the others, at lamellipodia to promote cell movement Homo sapiens