Literature summary for 2.7.1.91 extracted from

Schnitzer, S.E.; Weigert, A.; Zhou, J.; Bruene, B.
Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells (2009), Mol. Cancer Res., 7, 393-401.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	under hypoxia, isoform Sk2 shows an increase in protein level and activity, which correlates with the release of shingosine 1-phosphate into the medium	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	under hypoxia, isoform Sk2 shows an increase in protein level and activity, which correlates with the release of shingosine 1-phosphate into the medium. Knockdown of Sk2 by siRNA releives chemoresistance of A-450 cells under hypoxia and conditioned medium obtained from Sk2 knock-down cells is only partly protective, while conditioned medium of cells with normal levels of Sk2, incubated for 24 h under hypoxia, protects naive A-549 cells from etoposide-induced cell death	Homo sapiens

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Release 2023.1 (January 2023)