Literature summary for 2.7.1.91 extracted from

Serrano-Sanchez, M.; Tanfin, Z.; Leiber, D.
Signaling pathways involved in sphingosine kinase activation and sphingosine-1-phosphate release in rat myometrium in late pregnancy: role in the induction of COX2 (2008), Endocrinology, 49, 4669-4679.

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Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
myometrium	during gestation, isoforms Sphk1 and Sphk2 are co-expressed. The levels and activity of SphK1/2 are modest at midgestation , increase at day 19 and progressively decline to low at postpartum. Inhibition of protein kinase C and ERK reduces SphK1/2 activity. In primary cultures of myometrial cells from day 19 pregnant rats, induction of COX2 is mediated by 4-phorbol 12,13-dibutyrate and IL-1 through sequential activation of protein kinase C, ERK1/2, and SphK1. Sphingosine 1-phosphate produced by SphK1 is released in the medium. In day 12 myometrial tissues, the release of sphingosine 1-phosphate is markedly reduced in association with low levels of SphK1 and COX2	Rattus norvegicus	-

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Release 2023.1 (January 2023)