Literature summary for 2.7.1.91 extracted from

Gratschev, D.; Loef, C.; Heikkilae, J.; Bjoerkbom, A.; Sukumaran, P.; Hinkkanen, A.; Slotte, J.P.; Toernquist, K.
Sphingosine kinase as a regulator of calcium entry through autocrine sphingosine 1-phosphate signaling in thyroid FRTL-5 cells (2009), Endocrinology, 150, 5125-5134.

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Protein Variants

Protein Variants	Comment	Organism
G82D	dominant-negative mutant, calcium entry to cells is decreased in mutant lines. Exogenous sphingosine 1-phosphate restores calcium entry	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
FRTL-5 cell	thyroid cell	Rattus norvegicus	-

General Information

General Information	Comment	Organism
physiological function	inhibition of isoform Sk1 or the ATP-binding cassette ABCC1 multidrug transporter attenuates calcium entry to cells, the addition of exogenous sphingosine 1-phosphate restores calcium entry. Overexpression of wild-type isoform Sk1, but not sk2, enhances phosphatese inhibitor calyculin-evoked calcium entry, whereas calcium entry is decreased in cells transfected with the dominant-negative G82D Sk1 mutant	Rattus norvegicus

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Release 2023.1 (January 2023)