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Literature summary for 2.7.1.91 extracted from

  • Sukocheva, O.; Wang, L.; Verrier, E.; Vadas, M.A.; Xia, P.
    Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway (2009), Endocrinology, 150, 4484-4492.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
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Homo sapiens
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General Information

General Information Comment Organism
physiological function isoform Sk1 activity is causally associated with endocrine resistance in MCF-7 cells. Enforced overexpression of Sk1 results in enhanced cell proliferation and resistance to tamoxifen-induced cell growth arrest and apoptosis. Tamoxifen-resistant cells exhibit higher levels of Sk1 expression and activity. Inhibition of Sk1 by pharmaceutical inhibitors or the dominant-negative mutant G82D restores the antiproliferative and proapoptotic effect of tamoxifen. Silencing of isoform Sk1, but not Sk2, expression by siRNA also restores the tamoxifen responsiveness in the resistant cells Homo sapiens