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Literature summary for 2.7.1.91 extracted from
- Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-beta-stimulated collagen production by cardiac fibroblasts (2009), Cardiovasc. Res., 82, 303-312.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | - |
Mus musculus | - |
| heart | - |
Mus musculus | - |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | in cardiac fibroblasts, sphingosine 1-phosphate increases alpha-smooth muscle actin and collagen expression in a S1P2 receptor- and Rho-kinase-dependent manner. TGF-beta increases sphingosine kinase 1 expression and activity. TGF-beta-stimulated collagen production is inhibited by SphK1 or S1P2 siRNA, a SphK inhibitor, and an anti-S1P monoclonal antibody | Mus musculus |
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Release 2023.1 (January 2023)
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