Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R,3S,4E)-N-methyl-5-(4-pentylphenyl)-2-aminopent-4-ene-1,3-diol | i.e. SK1-I, BML-258, isotype-specific SphK1 inhibitor. Treatment suppresses growth of LN229 and U373 glioblastoma cell lines and nonestablished human GBM6 cells. SK1-I also enhances glioblastoma multiforma cell death and inhibits their migration and invasion. Sk1-I enhances the survival of mice harboring LN229 intracranial tumors. SK1-I rapidly reduces phosphorylation of Akt but has no significant effect on activation of extracellular signal-regulated kinase 1/2 | Homo sapiens | |
(2R,3S,4E)-N-methyl-5-(4-pentylphenyl)-2-aminopent-4-ene-1,3-diol | i.e. SK1-I, BML-258, isotype-specific SphK1 inhibitor. SK1-I markedly reduces the tumor growth rate of glioblastoma xenografts, inducing apoptosis and reducing tumor vascularization, and enhances the survival of mice harboring LN229 intracranial tumors | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
LN-229 cell | - |
Homo sapiens | - |
U-373MG cell | - |
Homo sapiens | - |