Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.91 extracted from

  • Ader, I.; Brizuela, L.; Bouquerel, P.; Malavaud, B.; Cuvillier, O.
    Sphingosine kinase 1: a new modulator of hypoxia inducible factor 1alpha during hypoxia in human cancer cells (2008), Cancer Res., 68, 8635-8642.
    View publication on PubMed
Search for more literature for 2.7.1.91

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
PC-3 cell
-
 Homo sapiens
-
RCC-10 cell
-
 Homo sapiens
-
SUM-159PT cell
-
 Homo sapiens
-
U-87MG cell
-
 Homo sapiens
-

General Information

General Information Comment Organism
physiological function SphK1 activity is stimulated under low oxygen conditions and regulated by reactive oxygen species. The SphK1-dependent stabilization of HIF-1alpha levels is mediated by the Akt/glycogen synthase kinase-3beta signaling pathway that prevents its von Hippel-Lindau protein–mediated degradation by the proteasome. The pharmacologic and RNA silencing inhibition of SphK1 activity prevents the accumulation of HIF-1A and its transcriptional activity in several human cancer cell lineages from prostate, brain, breast, kidney, and lung, suggesting a canonical pathway Homo sapiens