Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
PC-3 cell | - |
Homo sapiens | - |
RCC-10 cell | - |
Homo sapiens | - |
SUM-159PT cell | - |
Homo sapiens | - |
U-87MG cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | SphK1 activity is stimulated under low oxygen conditions and regulated by reactive oxygen species. The SphK1-dependent stabilization of HIF-1alpha levels is mediated by the Akt/glycogen synthase kinase-3beta signaling pathway that prevents its von Hippel-Lindau proteinmediated degradation by the proteasome. The pharmacologic and RNA silencing inhibition of SphK1 activity prevents the accumulation of HIF-1A and its transcriptional activity in several human cancer cell lineages from prostate, brain, breast, kidney, and lung, suggesting a canonical pathway | Homo sapiens |