Literature summary for 2.7.1.91 extracted from

Lidington, D.; Peter, B.F.; Meissner, A.; Kroetsch, J.T.; Pitson, S.M.; Pohl, U.; Bolz, S.S.
The phosphorylation motif at serine 225 governs the localization and function of sphingosine kinase 1 in resistance arteries (2009), Arterioscler. Thromb. Vasc. Biol., 29, 1916-1922.

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Protein Variants

Protein Variants	Comment	Organism
S225A	expression in resistance artery smooth muscle cells reduces resting and myogenic tone, resting Ca2+, pressure-induced Ca2+ elevations, and Ca2+ sensitivity. Lack of function of S225A can only partly be overcome by forced localization to the plasma membrane	Mesocricetus auratus

Organism

Organism	UniProt	Comment	Textmining
Mesocricetus auratus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	in muscle resistance artery, pressure-dependent activation and translocation of isoform Sk1 by ERK1/2 is critically dependent on its serine225 phosphorylation site	Mesocricetus auratus

Source Tissue

Source Tissue	Comment	Organism	Textmining
artery	gracilis muscle resistance artery. Pressure-dependent activation and translocation of isoform Sk1 by ERK1/2 is critically dependent on its serine225 phosphorylation site	Mesocricetus auratus	-
smooth muscle	gracilis muscle resistance artery. Pressure-dependent activation and translocation of isoform Sk1 by ERK1/2 is critically dependent on its serine225 phosphorylation site	Mesocricetus auratus	-

General Information

General Information	Comment	Organism
physiological function	translocation and precise subcellular positioning of Sk1 is essential for full function, and two distinct sphingosin 1-phosphate pools, intra- and extracellular, contribute to the maintenance of vascular tone	Mesocricetus auratus

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Release 2023.1 (January 2023)