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Literature summary for 2.7.1.91 extracted from

  • Kono, Y.; Nishiuma, T.; Nishimura, Y.; Kotani, Y.; Okada, T.; Nakamura, S.; Yokoyama, M.
    Sphingosine kinase 1 regulates differentiation of human and mouse lung fibroblasts mediated by TGF-beta1 (2007), Am. J. Respir. Cell Mol. Biol., 37, 395-404.
    View publication on PubMed
Search for more literature for 2.7.1.91

Activating Compound

Activating Compound Comment Organism Structure
additional information SPHK2 is not activated by transforming growth factor beta1 Homo sapiens
transforming growth factor beta1 5ng/ml Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-(p-hydroxyanilino)-4-(p-chlorophenyl) thiazole 0.005 mM Homo sapiens
N,N-dimethylsphingosine 0.005 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NRA0
-
-
Homo sapiens Q9NYA1
-
-
Mus musculus Q8CI15
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bronchial epithelial cell
-
 Mus musculus
-
lung fibroblast
-
 Homo sapiens
-
lung fibroblast
-
 Mus musculus
-
smooth muscle cell
-
 Mus musculus
-
vascular endothelial cell
-
 Mus musculus
-
WI-38 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + sphingosine
-
 Homo sapiens ADP + sphingosine 1-phosphate
-
 ?
ATP + sphingosine
-
 Mus musculus ADP + sphingosine 1-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
sphingosine kinase 1
-
 Homo sapiens
sphingosine kinase 1
-
 Mus musculus
sphingosine kinase 2
-
 Homo sapiens
SPHK1
-
 Homo sapiens
SPHK1
-
 Mus musculus
SPHK2
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens
ATP
-
 Mus musculus