Cloned (Comment) | Organism |
---|---|
isozymes SPHK1 and SPHK2, expression in HEK293 cells as EGFP-fusion proteins | Mus musculus |
isozymes SPHK1 and SPHK2, several splicing variants are differently active, expression in HEK293 cells as EGFP-fusion proteins | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics, isozymes SPHK1 and SPHK2 | Homo sapiens | |
additional information | - |
additional information | kinetics, isozymes SPHK1 and SPHK2 | Mus musculus | |
0.013 | - |
sphingosine | pH 7.4, 30°C, recombinant isozyme SPHK1a | Mus musculus | |
0.013 | - |
sphingosine | pH 7.4, 30°C, recombinant isozyme SPHK2 | Mus musculus | |
0.014 | - |
sphingosine | pH 7.4, 30°C, recombinant isozyme SPHK2 | Homo sapiens | |
0.016 | - |
sphingosine | pH 7.4, 30°C, recombinant isozyme SPHK1 | Homo sapiens | |
0.018 | - |
FTY720 | pH 7.4, 30°C, recombinant isozyme SPHK2 | Homo sapiens | |
0.024 | - |
FTY720 | pH 7.4, 30°C, recombinant isozyme SPHK2 | Mus musculus | |
0.692 | - |
FTY720 | about, pH 7.4, 30°C, recombinant isozyme SPHK1a | Mus musculus | |
0.785 | - |
FTY720 | about, pH 7.4, 30°C, recombinant isozyme SPHK1 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
cytosol | major part of isozyme SPHK1 and isozyme SPHK2 | Mus musculus | 5829 | - |
particle-bound | - |
Mus musculus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + sphinganine | Homo sapiens | - |
ADP + sphinganine 1-phosphate | - |
? | |
ATP + sphinganine | Mus musculus | - |
ADP + sphinganine 1-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NRA0 | isozyme SPHK2; 2 isozymes SPHK1 and SPHK2, several splicing variants | - |
Homo sapiens | Q9NYA1 | isozyme SPHK1; 2 isozymes SPHK1 and SPHK2, several splicing variants | - |
Mus musculus | O88885 | isozyme SPHK1; 2 isozymes SPHK1 and SPHK2, several splicing variants | - |
Mus musculus | Q9JIA7 | isozyme SPHK2; 2 isozymes SPHK1 and SPHK2, several splicing variants | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | higher activity of isozyme SPHK1, low activity of isozyme SPHK2 | Homo sapiens | - |
blood | higher activity of isozyme SPHK1, low activity of isozyme SPHK2 | Mus musculus | - |
brain | quite low activity of isozyme SPHK1 and isozyme SPHK2 | Mus musculus | - |
endothelial cell | - |
Homo sapiens | - |
kidney | isozyme SPHK1 and isozyme SPHK2 | Mus musculus | - |
liver | high activity of isozyme SPHK2, low activity of isozyme SPHK1 | Mus musculus | - |
lung | high activity of isozyme SPHK1, low activity of isozyme SPHK2 | Mus musculus | - |
lymph node | low activity of isozyme SPHK1 and isozyme SPHK2 | Mus musculus | - |
additional information | tissue distribution of isozyme SPHK1 and isozyme SPHK2 expression and activity, overview | Mus musculus | - |
spleen | isozyme SPHK1, low activity of isozyme SPHK2 | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
Vmax of different splicing variants of both isozymes | Homo sapiens |
additional information | - |
Vmax of different splicing variants of both isozymes | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + FTY720 | immunomodulatory drug, high activity with isozyme SPHK2, 7fold lower activity with isozyme SPHK1 | Homo sapiens | ADP + FTY720 1-phosphate | - |
? | |
ATP + FTY720 | immunomodulatory drug, high activity with isozyme SPHK2, lower activity with isozyme SPHK1 | Mus musculus | ADP + FTY720 1-phosphate | - |
? | |
ATP + sphinganine | - |
Homo sapiens | ADP + sphinganine 1-phosphate | - |
? | |
ATP + sphinganine | - |
Mus musculus | ADP + sphinganine 1-phosphate | - |
? | |
ATP + sphinganine | 2fold higher activity with isozyme SPHK1 compared to isozyme SPHK2 | Homo sapiens | ADP + sphinganine 1-phosphate | - |
? | |
ATP + sphingosine | - |
Mus musculus | ADP + sphingosine 1-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | enzyme belongs to the SPHK superfamily | Homo sapiens |
More | enzyme belongs to the SPHK superfamily | Mus musculus |
sphinganine kinase | - |
Homo sapiens |
sphinganine kinase | - |
Mus musculus |
SPHK | - |
Homo sapiens |
SPHK | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
30 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
7.4 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | binding site contain the GGDGX20K motif | Homo sapiens | |
ATP | binding site contains the GGDGX20K motif | Homo sapiens |