Any feedback?
Literature summary for 2.7.1.91 extracted from
- Distribution of sphingosine kinase activity in mouse tissues: contribution of SPHK1 (2003), Biochem. Biophys. Res. Commun., 309, 155-160.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | about 30% of total activity | Mus musculus | 16020 | - |
| soluble | about 70% of total activity | Mus musculus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + sphingosine | Mus musculus | - |
ADP + sphingosine 1-phosphate | short-living product S1P is a bioactive lipid mediator in diverse cellular processes, e.g. regulation of cell differentiation, motility, and apoptosis both extracellularly via S1P family receptors and intracellularly | ? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
male C57BL mice, 2 isozymes SPHK1 and SPHK2, isozyme SPHK1 exists in 2 splicing variants a and b | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood platelet | - |
Mus musculus | - |
| brain | major isozyme is SPHK1 | Mus musculus | - |
| colon | major isozyme is SPHK1 | Mus musculus | - |
| heart | major isozyme is SPHK1 | Mus musculus | - |
| kidney | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
| lung | high activity, isozymes SPHK1 and SPHK2 | Mus musculus | - |
| additional information | isozyme tissue distribution patterns | Mus musculus | - |
| pancreas | - |
Mus musculus | - |
| skeletal muscle | very low activity | Mus musculus | - |
| small intestine | isozymes SPHK1 and SPHK2 | Mus musculus | - |
| spleen | isozymes SPHK1 and SPHK2 | Mus musculus | - |
| stomach | - |
Mus musculus | - |
| testis | - |
Mus musculus | - |
| thymus | high activity | Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.000002 | - |
skeletal muscle homogenate | Mus musculus |
| 0.00003 | - |
liver homogenate | Mus musculus |
| 0.00004 | 0.00005 | homogenates of kidney, colon, stomach, pancreas, and heart | Mus musculus |
| 0.00006 | 0.00007 | homogenates of testis, brain, and platelet | Mus musculus |
| 0.00009 | - |
homogenates of small intestine and spleen | Mus musculus |
| 0.00016 | - |
thymus homogenate | Mus musculus |
| 0.00024 | - |
lung homogenate | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + sphingosine | - |
Mus musculus | ADP + sphingosine 1-phosphate | short-living product S1P is a bioactive lipid mediator in diverse cellular processes, e.g. regulation of cell differentiation, motility, and apoptosis both extracellularly via S1P family receptors and intracellularly | ? | |
| ATP + sphingosine | isozymes SPHK1 is about 100fold more active than isozyme SPHK2 | Mus musculus | ADP + sphingosine 1-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| sphinganine kinase | - |
Mus musculus |
| SPHK | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
