Application | Comment | Organism |
---|---|---|
pharmacology | the enzyme is a critical determinant of therapeutic activity for several nucleoside analogue prodrugs | Mus musculus |
pharmacology | the enzyme is a critical determinant of therapeutic activity for several nucleoside analogue prodrugs | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00061 | - |
1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-chlorocytosine | pH 7.6, 37°C, recombinant enzyme | Homo sapiens | |
0.00076 | - |
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine | pH 7.6, 37°C, recombinant enzyme | Homo sapiens | |
0.00102 | - |
1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methylcytosine | pH 7.6, 37°C, recombinant enzyme | Homo sapiens | |
0.00654 | - |
1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-bromocytosine | pH 7.6, 37°C, recombinant enzyme | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
cytosol | - |
Homo sapiens | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Mus musculus | |
Mg2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + deoxyadenosine | Mus musculus | - |
ADP + dAMP | - |
? | |
ATP + deoxyadenosine | Homo sapiens | - |
ADP + dAMP | - |
? | |
ATP + deoxyadenosine | Mus musculus C57/BL6J | - |
ADP + dAMP | - |
? | |
ATP + deoxycytidine | Mus musculus | - |
ADP + dCMP | - |
? | |
ATP + deoxycytidine | Homo sapiens | - |
ADP + dCMP | - |
? | |
ATP + deoxycytidine | Mus musculus C57/BL6J | - |
ADP + dCMP | - |
? | |
ATP + deoxyguanosine | Mus musculus | - |
ADP + dGMP | - |
? | |
ATP + deoxyguanosine | Homo sapiens | - |
ADP + dGMP | - |
? | |
ATP + deoxyguanosine | Mus musculus C57/BL6J | - |
ADP + dGMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Mus musculus C57/BL6J | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | dCK-negative L1210-10K tumors | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine | - |
Mus musculus | ADP + 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine monophosphate | - |
? | |
ATP + 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine | - |
Homo sapiens | ADP + 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine monophosphate | - |
? | |
ATP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-bromocytosine | - |
Mus musculus | ADP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-bromocytosine monophosphate | - |
? | |
ATP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-bromocytosine | - |
Homo sapiens | ADP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-bromocytosine monophosphate | - |
? | |
ATP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-chlorocytosine | - |
Mus musculus | ADP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-chlorocytosine monophosphate | - |
? | |
ATP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-chlorocytosine | - |
Homo sapiens | ADP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-chlorocytosine monophosphate | - |
? | |
ATP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methylcytosine | - |
Mus musculus | ADP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methylcytosine monophosphate | - |
? | |
ATP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methylcytosine | - |
Homo sapiens | ADP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methylcytosine monophosphate | - |
? | |
ATP + clofarabine | - |
Mus musculus | ADP + clofarabine 5'-phosphate | - |
? | |
ATP + clofarabine | - |
Homo sapiens | ADP + clofarabine 5'-phosphate | - |
? | |
ATP + clofarabine | - |
Mus musculus C57/BL6J | ADP + clofarabine 5'-phosphate | - |
? | |
ATP + deoxyadenosine | - |
Mus musculus | ADP + dAMP | - |
? | |
ATP + deoxyadenosine | - |
Homo sapiens | ADP + dAMP | - |
? | |
ATP + deoxyadenosine | - |
Mus musculus C57/BL6J | ADP + dAMP | - |
? | |
ATP + deoxycytidine | - |
Mus musculus | ADP + dCMP | - |
? | |
ATP + deoxycytidine | - |
Homo sapiens | ADP + dCMP | - |
? | |
ATP + deoxycytidine | - |
Mus musculus C57/BL6J | ADP + dCMP | - |
? | |
ATP + deoxyguanosine | - |
Mus musculus | ADP + dGMP | - |
? | |
ATP + deoxyguanosine | - |
Homo sapiens | ADP + dGMP | - |
? | |
ATP + deoxyguanosine | - |
Mus musculus C57/BL6J | ADP + dGMP | - |
? | |
additional information | 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)uracil is no substrate. But 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine can be converted to 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)uracil by cytidine deaminase | Mus musculus | ? | - |
? | |
additional information | 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)uracil is no substrate. But 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine can be converted to 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)uracil by cytidine deaminase | Homo sapiens | ? | - |
? | |
additional information | 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)uracil is no substrate. But 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine can be converted to 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)uracil by cytidine deaminase | Mus musculus C57/BL6J | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dCK | - |
Mus musculus |
dCK | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
assay at | Mus musculus |
7.6 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | deoxycytidine kinase is a rate-limiting enzyme in the deoxyribonucleoside salvage pathway | Mus musculus |
metabolism | deoxycytidine kinase is a rate-limiting enzyme in the deoxyribonucleoside salvage pathway | Homo sapiens |
additional information | biodistribution of cytosine derivative substrates in mouse healthy and malignant tissues, overview | Mus musculus |