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Literature summary for 2.7.1.74 extracted from

  • Shu, C.J.; Campbell, D.O.; Lee, J.T.; Tran, A.Q.; Wengrod, J.C.; Witte, O.N.; Phelps, M.E.; Satyamurthy, N.; Czernin, J.; Radu, C.G.
    Novel PET probes specific for deoxycytidine kinase (2010), J. Nucl. Med., 51, 1092-1098.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
pharmacology the enzyme is a critical determinant of therapeutic activity for several nucleoside analogue prodrugs Mus musculus
pharmacology the enzyme is a critical determinant of therapeutic activity for several nucleoside analogue prodrugs Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00061
-
1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-chlorocytosine pH 7.6, 37°C, recombinant enzyme Homo sapiens
0.00076
-
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine pH 7.6, 37°C, recombinant enzyme Homo sapiens
0.00102
-
1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methylcytosine pH 7.6, 37°C, recombinant enzyme Homo sapiens
0.00654
-
1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-bromocytosine pH 7.6, 37°C, recombinant enzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mus musculus 5829
-
cytosol
-
Homo sapiens 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mus musculus
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + deoxyadenosine Mus musculus
-
ADP + dAMP
-
?
ATP + deoxyadenosine Homo sapiens
-
ADP + dAMP
-
?
ATP + deoxyadenosine Mus musculus C57/BL6J
-
ADP + dAMP
-
?
ATP + deoxycytidine Mus musculus
-
ADP + dCMP
-
?
ATP + deoxycytidine Homo sapiens
-
ADP + dCMP
-
?
ATP + deoxycytidine Mus musculus C57/BL6J
-
ADP + dCMP
-
?
ATP + deoxyguanosine Mus musculus
-
ADP + dGMP
-
?
ATP + deoxyguanosine Homo sapiens
-
ADP + dGMP
-
?
ATP + deoxyguanosine Mus musculus C57/BL6J
-
ADP + dGMP
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Mus musculus C57/BL6J
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information dCK-negative L1210-10K tumors Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine
-
Mus musculus ADP + 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine monophosphate
-
?
ATP + 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine
-
Homo sapiens ADP + 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine monophosphate
-
?
ATP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-bromocytosine
-
Mus musculus ADP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-bromocytosine monophosphate
-
?
ATP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-bromocytosine
-
Homo sapiens ADP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-bromocytosine monophosphate
-
?
ATP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-chlorocytosine
-
Mus musculus ADP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-chlorocytosine monophosphate
-
?
ATP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-chlorocytosine
-
Homo sapiens ADP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-chlorocytosine monophosphate
-
?
ATP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methylcytosine
-
Mus musculus ADP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methylcytosine monophosphate
-
?
ATP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methylcytosine
-
Homo sapiens ADP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methylcytosine monophosphate
-
?
ATP + clofarabine
-
Mus musculus ADP + clofarabine 5'-phosphate
-
?
ATP + clofarabine
-
Homo sapiens ADP + clofarabine 5'-phosphate
-
?
ATP + clofarabine
-
Mus musculus C57/BL6J ADP + clofarabine 5'-phosphate
-
?
ATP + deoxyadenosine
-
Mus musculus ADP + dAMP
-
?
ATP + deoxyadenosine
-
Homo sapiens ADP + dAMP
-
?
ATP + deoxyadenosine
-
Mus musculus C57/BL6J ADP + dAMP
-
?
ATP + deoxycytidine
-
Mus musculus ADP + dCMP
-
?
ATP + deoxycytidine
-
Homo sapiens ADP + dCMP
-
?
ATP + deoxycytidine
-
Mus musculus C57/BL6J ADP + dCMP
-
?
ATP + deoxyguanosine
-
Mus musculus ADP + dGMP
-
?
ATP + deoxyguanosine
-
Homo sapiens ADP + dGMP
-
?
ATP + deoxyguanosine
-
Mus musculus C57/BL6J ADP + dGMP
-
?
additional information 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)uracil is no substrate. But 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine can be converted to 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)uracil by cytidine deaminase Mus musculus ?
-
?
additional information 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)uracil is no substrate. But 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine can be converted to 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)uracil by cytidine deaminase Homo sapiens ?
-
?
additional information 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)uracil is no substrate. But 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine can be converted to 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)uracil by cytidine deaminase Mus musculus C57/BL6J ?
-
?

Synonyms

Synonyms Comment Organism
dCK
-
Mus musculus
dCK
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
assay at Mus musculus
7.6
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus
ATP
-
Homo sapiens

General Information

General Information Comment Organism
metabolism deoxycytidine kinase is a rate-limiting enzyme in the deoxyribonucleoside salvage pathway Mus musculus
metabolism deoxycytidine kinase is a rate-limiting enzyme in the deoxyribonucleoside salvage pathway Homo sapiens
additional information biodistribution of cytosine derivative substrates in mouse healthy and malignant tissues, overview Mus musculus