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Literature summary for 2.7.1.74 extracted from

  • Weng, T.; Karmouty-Quintana, H.; Garcia-Morales, L.J.; Molina, J.G.; Pedroza, M.; Bunge, R.R.; Bruckner, B.A.; Loebe, M.; Seethamraju, H.; Blackburn, M.R.
    Hypoxia-induced deoxycytidine kinase expression contributes to apoptosis in chronic lung disease (2013), FASEB J., 27, 2013-2026.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.74

Cloned(Commentary)

Cloned (Comment) Organism
quantitative RT-PCR expression analysis Mus musculus
quantitative RT-PCR expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information for enzyme knockout, MLE12 cells are transfected with DCK siRNA Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
 Ada-/- mice
-

Source Tissue

Source Tissue Comment Organism Textmining
MLE-12 cell
-
 Mus musculus
-
pulmonary epithelial cell
-
 Mus musculus
-
pulmonary epithelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NTP + deoxyadenosine
-
 Mus musculus NDP + dAMP
-
 ?
NTP + deoxyadenosine
-
 Homo sapiens NDP + dAMP
-
 ?
NTP + deoxycytidine
-
 Homo sapiens NDP + dCMP
-
 ?

Synonyms

Synonyms Comment Organism
dCK
-
 Mus musculus
dCK
-
 Homo sapiens

Expression

Organism Comment Expression
Mus musculus the enzyme is hypoxia-induced up
Homo sapiens the enzyme is hypoxia-induced up

General Information

General Information Comment Organism
malfunction inhibition of the enzyme results in diminished dAdomediated apoptosis in the lungs Homo sapiens
malfunction inhibition of the enzyme results in diminished deoxyadenosine-mediated apoptosis in the lungs Mus musculus
physiological function deoxycitidine kinase is a major enzyme for deoxyadenosine phosphorylation. Hypoxia-induced deoxycytidine kinase expression contributes to apoptosis in chronic lung disease, hypoxia is a regulator of the enzyme Homo sapiens
physiological function deoxycitidine kinase is a major enzyme for deoxyadenosine phosphorylation. Hypoxia-induced deoxycytidine kinase expression contributes to apoptosis in chronic lung disease, hypoxia is a regulator of the enzyme. Activating the dAdo-DCK-dATP pathway directly results in increased apoptosis in the lungs of mice with air-space enlargement, the dAdo-DCK pathway is activated in the lungs of Ada-/- mice, overview Mus musculus