Cloned (Comment) | Organism |
---|---|
expression in Cos-1 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | sequencing of deoxycytidine kinase and cytidine monophosphate kinase using 240 DNA samples reveals 28 polymorphisms in deoxycytidine kinase. Variant allozyme enzyme activities range from 32% to 105% of the wild type activity with no significant differences in apparent Km values except for a V24/S122 double variant enzyme. Relative levels of immunoreactive protein after expression in COS-1 cells parallel relative levels of enzyme activity | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0146 | - |
2',2'-difluorodeoxycytidine | wild-type | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27707 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 2',2'-difluorodeoxycytidine | i.e. gemcitabine | Homo sapiens | ADP + 2',2'-difluorodeoxycytidine 5'-monophosphate | - |
? |