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Literature summary for 2.7.1.74 extracted from

  • Sebastiani, V.; Ricci, F.; Rubio-Viqueira, B.; Rubio-Viquiera, B.; Kulesza, P.; Yeo, C.J.; Hidalgo, M.; Klein, A.; Laheru, D.; Iacobuzio-Donahue, C.A.
    Immunohistochemical and genetic evaluation of deoxycytidine kinase in pancreatic cancer: relationship to molecular mechanisms of gemcitabine resistance and survival (2006), Clin. Cancer Res., 12, 2492-2497.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.74

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NTP + 2',2'-difluorodeoxycytidine Homo sapiens i.e. gemcitabine, rate limiting enzyme in the activation of the pharmaceutically relevant substrate which is commonly used in the treatment of solid malignant tumors NDP + 2',2'-difluorodeoxycytidine 5'-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 patients suffering from pancreatic cancer, survival of patients is found to be correlated to the detected enzyme level
-

Source Tissue

Source Tissue Comment Organism Textmining
AsPC-1 cell
-
 Homo sapiens
-
BxPC3 cell
-
 Homo sapiens
-
CAPAN-1 cell
-
 Homo sapiens
-
CAPAN-2 cell
-
 Homo sapiens
-
CFPAC cell
-
 Homo sapiens
-
HS578 cell
-
 Homo sapiens
-
HS766T cell
-
 Homo sapiens
-
MiaPaCa-2 cell
-
 Homo sapiens
-
PANC-1 cell
-
 Homo sapiens
-
pancreas pancreatic cancer tissue, enzyme detected in 40 out of 44 patient samples Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NTP + 2',2'-difluorodeoxycytidine i.e. gemcitabine, rate limiting enzyme in the activation of the pharmaceutically relevant substrate which is commonly used in the treatment of solid malignant tumors Homo sapiens NDP + 2',2'-difluorodeoxycytidine 5'-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
dCK
-
 Homo sapiens