Cloned (Comment) | Organism |
---|---|
expressed as His-tag fusion protein in Escherichia coli BL21(DE3) | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
hanging drop vapour diffusion method, in complex with 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine and ADP | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NTP + 2'-deoxyadenosine | Homo sapiens | - |
NDP + 2'-deoxyadenosine 5'-phosphate | - |
? | |
NTP + 2'-deoxycytidine | Homo sapiens | more effective substrate than 2'-deoxyadenosine and 2'-deoxyguanosine | NDP + 2'-deoxycytidine 5'-phosphate | - |
? | |
NTP + 2'-deoxyguanosine | Homo sapiens | - |
NDP + 2'-deoxyguanosine 5'-phosphate | - |
? | |
NTP + 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine | Homo sapiens | i.e. clofarabine, rate-limiting step in the activation of the prodrug, precursor of an effective chemotherapeutic agent for leukemias and other haematological malignancies | NDP + 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine 5'-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27707 | - |
- |
Purification (Comment) | Organism |
---|---|
recombinant protein using His-tag | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NTP + 2'-deoxyadenosine | - |
Homo sapiens | NDP + 2'-deoxyadenosine 5'-phosphate | - |
? | |
NTP + 2'-deoxycytidine | more effective substrate than 2'-deoxyadenosine and 2'-deoxyguanosine | Homo sapiens | NDP + 2'-deoxycytidine 5'-phosphate | - |
? | |
NTP + 2'-deoxyguanosine | - |
Homo sapiens | NDP + 2'-deoxyguanosine 5'-phosphate | - |
? | |
NTP + 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine | i.e. clofarabine, rate-limiting step in the activation of the prodrug, precursor of an effective chemotherapeutic agent for leukemias and other haematological malignancies | Homo sapiens | NDP + 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine 5'-phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | crystal structure analysis | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
dCK | - |
Homo sapiens |