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Literature summary for 2.7.1.74 extracted from

  • Hubeek, I.; Peters, G.J.; Broekhuizen, A.J.F.; Talianidis, I.; Sigmond, J.; Gibson, B.E.S.; Creutzig, U.; Giaccone, G.; Kaspers, G.J.L.
    Immunocytochemical detection of deoxycytidine kinase in haematological malignancies and solid tumours (2005), J. Clin. Pathol., 58, 695-699.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.74

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 2'-deoxycytidine Homo sapiens
-
 ADP + 2'-deoxycytidine 5'-phosphate
-
 ?
ATP + 2-chlorodeoxyadenosine Homo sapiens i.e. cladribine ADP + 2-chlorodeoxyadenosine 5'-phosphate
-
 ?
additional information Homo sapiens the enzyme is active and important in activation of several clinically important deoxynucleoside analogues used for the treatment of haematological and solid malignancies ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain tumor cell paediatric Homo sapiens
-
CCRF-CEM cell
-
 Homo sapiens
-
HL-60 cell
-
 Homo sapiens
-
lung cancer cell adult non-small cell lung cancer Homo sapiens
-
additional information enzyme level in case of acute myeloid leukemia and acute lymphoblastic leukemia in 97 patients, expression levels in different cancer cells, overview Homo sapiens
-
retinoblastoma cell
-
 Homo sapiens
-
U-937 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2'-deoxycytidine
-
 Homo sapiens ADP + 2'-deoxycytidine 5'-phosphate
-
 ?
ATP + 2-chlorodeoxyadenosine i.e. cladribine Homo sapiens ADP + 2-chlorodeoxyadenosine 5'-phosphate
-
 ?
additional information the enzyme is active and important in activation of several clinically important deoxynucleoside analogues used for the treatment of haematological and solid malignancies Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
dCK
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens