Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4'-thio-beta-D-arabinofuranosylcytosine | IC50 0.000024 mM | Homo sapiens | |
5-chloro-4'-thio-beta-D-arabinofuranosylcytosine | IC50 0.051 mM | Homo sapiens | |
5-fluoro-4'-thio-beta-D-arabinofuranosylcytosine | IC50 0.0000020 mM | Homo sapiens | |
cytosine arabinoside | IC50 0.0000055 mM | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00013 | - |
deoxycytidine | cosubstrate UTP 37°C, pH 8.0 | Homo sapiens | |
0.00032 | - |
4'-thio-2'-deoxycytidine | cosubstrate ATP 37°C, pH 8.0 | Homo sapiens | |
0.00041 | - |
beta-D-arabinofuranosylcytosine | cosubstrate UTP 37°C, pH 8.0 | Homo sapiens | |
0.00057 | - |
deoxycytidine | cosubstrate ATP 37°C, pH 8.0 | Homo sapiens | |
0.015 | - |
beta-D-arabinofuranosylcytosine | cosubstrate ATP 37°C, pH 8.0 | Homo sapiens | |
0.02 | - |
4'-thio-beta-D-arabinofuranosylcytosine | cosubstrate UTP 37°C, pH 8.0 | Homo sapiens | |
0.088 | - |
4'-thio-beta-D-arabinofuranosylcytosine | cosubstrate ATP 37°C, pH 8.0 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UTP + deoxycytidine | Homo sapiens | UTP is physiological phosphate donor | UDP + dCMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4'-thio-2'-deoxycytidine + UTP | - |
Homo sapiens | UDP + 4'-thio-2'-deoxycytidine 5'-phosphate | - |
? | |
4'-thio-beta-D-arabinofuranosylcytosine + UTP | - |
Homo sapiens | UDP + 4'-thio-beta-D-arabinofuranosylcytosine 5'-phosphate | - |
? | |
NTP + cytosine arabinoside | - |
Homo sapiens | NDP + cytosine arabinoside 5'-monophosphate | - |
? | |
NTP + deoxycytidine | - |
Homo sapiens | NDP + dCMP | - |
? | |
UTP + deoxycytidine | UTP is physiological phosphate donor | Homo sapiens | UDP + dCMP | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000002 | - |
IC50 0.0000020 mM | Homo sapiens | 5-fluoro-4'-thio-beta-D-arabinofuranosylcytosine | |
0.0000055 | - |
IC50 0.0000055 mM | Homo sapiens | cytosine arabinoside | |
0.000024 | - |
IC50 0.000024 mM | Homo sapiens | 4'-thio-beta-D-arabinofuranosylcytosine | |
0.051 | - |
IC50 0.051 mM | Homo sapiens | 5-chloro-4'-thio-beta-D-arabinofuranosylcytosine |