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Literature summary for 2.7.1.68 extracted from

  • Thapa, N.; Choi, S.; Tan, X.; Wise, T.; Anderson, R.A.
    Phosphatidylinositol phosphate 5-kinase Igamma and phosphoinositide 3-kinase/Akt signaling couple to promote oncogenic growth (2015), J. Biol. Chem., 290, 18843-18854.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Homo sapiens
-
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CAL-51 cell
-
Homo sapiens
-
HCC-1954 cell
-
Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-
MDA-MB-231 cell
-
Homo sapiens
-
SUM-1315MO2 cell
-
Homo sapiens
-
SUM-159PT cell
-
Homo sapiens
-
T-47D cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
?

Synonyms

Synonyms Comment Organism
phosphatidylinositol 4-phosphate 5-kinase Igamma
-
Homo sapiens
PIPKIgamma
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is overexpressed in triple-negative breast cancers up

General Information

General Information Comment Organism
malfunction enzyme knockdown impairs Akt activation in response to both FBS and ECM protein stimulation Homo sapiens
physiological function enzyme overexpression promotes class I PI3K and the serine/threoninespecific protein kinase Akt signaling and oncogenic growth Homo sapiens