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Literature summary for 2.7.1.68 extracted from

  • Nguyen, T.T.; Kim, Y.M.; Kim, T.D.; Le, O.T.; Kim, J.J.; Kang, H.C.; Hasegawa, H.; Kanaho, Y.; Jou, I.; Lee, S.Y.
    Phosphatidylinositol 4-phosphate 5-kinase alpha facilitates toll-like receptor 4-mediated microglial inflammation through regulation of the toll/interleukin-1 receptor domain-containing adaptor protein (TIRAP) location (2013), J. Biol. Chem., 288, 5645-5659.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression of isozyme PIP5Kalpha tagged with monomeric red fluorescent protein, haemagglutinin, or FLAG in HEK-293T cells Mus musculus

Protein Variants

Protein Variants Comment Organism
D309N inactive mutant Homo sapiens
additional information construction of PIP5Kalpha knockdown BV-2 cells by shRNA Mus musculus
R332H YFP-tagged tubby mutant Mus musculus
R427Q inactive mutant Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozymes PIP5Kalpha, PIP5Kbeta, and PIP5Kgamma
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Mus musculus P70182 isozymes PIP5Kalpha, PIP5Kbeta, and PIP5Kgamma
-

Source Tissue

Source Tissue Comment Organism Textmining
BV-2 cell isozymes type I PIP5Kalpha, PIP5Kbeta, and PIP5Kgamma are all expressed in BV-2 microglial cells Mus musculus
-
microglial cell
-
 Homo sapiens
-
microglial cell isozymes type I PIP5Kalpha, PIP5Kbeta, and PIP5Kgamma are all expressed in BV-2 microglial cells Mus musculus
-

Synonyms

Synonyms Comment Organism
phosphatidylinositol 4-phosphate 5-kinase alpha
-
 Homo sapiens
phosphatidylinositol 4-phosphate 5-kinase alpha
-
 Mus musculus
PI 4-phosphate 5-kinase
-
 Homo sapiens
PI 4-phosphate 5-kinase
-
 Mus musculus
PIP5K
-
 Homo sapiens
PIP5K
-
 Mus musculus
PIP5Kalpha
-
 Homo sapiens
PIP5Kalpha
-
 Mus musculus
type I PI 4-phosphate 5-kinase
-
 Homo sapiens
type I PI 4-phosphate 5-kinase
-
 Mus musculus

General Information

General Information Comment Organism
malfunction isozyme PIP5Kalpha knockdown reduces 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate levels and disrupts Toll/IL-1 receptor domain-containing adaptor protein membrane targeting by lipopolysaccharide Homo sapiens
malfunction isozyme PIP5Kalpha knockdown reduces 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate levels and disrupts Toll/IL-1 receptor domain-containing adaptor protein membrane targeting by lipopolysaccharide. Isozyme PIP5Kalpha shRNA-15 knockdown cells are less effective inducing iNOS protein expression and nitric oxide production after lipopolysaccharide stimulation overnight and for 24 h, respectively, compared with control cells Mus musculus
metabolism phosphorylation of 1-phosphatidyl-1D-myo-inositol 4-phosphate by the type I PI 4-phosphate 5-kinase (PIP5K) family members including PIP5Kalpha, PIP5Kbeta, and PIP5Kgamma isoforms is the major pathway of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis in mammalian cells Homo sapiens
metabolism phosphorylation of 1-phosphatidyl-1D-myo-inositol 4-phosphate by the type I PI 4-phosphate 5-kinase (PIP5K) family members including PIP5Kalpha, PIP5Kbeta, and PIP5Kgamma isoforms is the major pathway of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis in mammalian cells Mus musculus
physiological function 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate regulates many critical cellular events and mediates plasma membrane localization of the Toll/IL-1 receptor domain-containing adaptor protein (TIRAP), required for the MyD88-dependent Toll-like receptor 4 signaling pathway. Phosphatidylinositol 4-phosphate 5-kinase alpha facilitates toll-like receptor 4-mediated microglial inflammation through regulation of the toll/interleukin-1 receptor domain-containing adaptor protein location Homo sapiens
physiological function 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate regulates many critical cellular events and mediates plasma membrane localization of the Toll/IL-1 receptor domain-containing adaptor protein (TIRAP), required for the MyD88-dependent Toll-like receptor 4 signaling pathway. Phosphatidylinositol 4-phosphate 5-kinase alpha facilitates toll-like receptor 4-mediated microglial inflammation through regulation of the toll/interleukin-1 receptor domain-containing adaptor protein location Mus musculus