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Literature summary for 2.7.1.68 extracted from

  • Gallicchio, M.A.; Bach, L.A.
    Advanced glycation end products inhibit Na+ K+ ATPase in proximal tubule epithelial cells: role of cytosolic phospholipase A2alpha and phosphatidylinositol 4-phosphate 5-kinase gamma (2010), Biochim. Biophys. Acta, 1803, 919-930.
    View publication on PubMed
Search for more literature for 2.7.1.68

Activating Compound

Activating Compound Comment Organism Structure
advanced glycation end products may stimulate PIP5Kgamma to increase 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate production, which may enhance adaptor protein complex 2 localisation to clathrin pits, increase clathrin pit formation, enhance renal Na+/K+ ATPase cargo recognition by adaptor protein complex 2 and/or stimulate cytosolic phospholipase A2 alpha activity Homo sapiens
advanced glycation end products may stimulate PIP5Kgamma to increase 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate production, which may enhance adaptor protein complex 2 localisation to clathrin pits, increase clathrin pit formation, enhance renal Na+/K+ ATPase cargo recognition by adaptor protein complex 2 and/or stimulate cytosolic phospholipase A2 alpha activity Sus scrofa

Protein Variants

Protein Variants Comment Organism
additional information PIP5Kgamma isozyme knockout by siRNA. Transfection of HK2 cells with PIP5Kgamma siRNA prevents advanced glycation end products-bovine serum albumin inhibition of renal Na+/K+ ATPase activity Homo sapiens
additional information PIP5Kgamma isozyme knockout by siRNA. Transfection of HK2 cells with PIP5Kgamma siRNA prevents advanced glycation end products-bovine serum albumin inhibition of renal Na+/K+ ATPase activity Sus scrofa

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens
Mg2+ required Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Homo sapiens
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Sus scrofa
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell
-
 Homo sapiens
-
HK-2 cell
-
 Homo sapiens
-
LLC-PK1 cell
-
 Sus scrofa
-
proximale tubular epithelium
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Sus scrofa ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
phosphatidylinositol 4-phosphate 5-kinase gamma
-
 Homo sapiens
phosphatidylinositol 4-phosphate 5-kinase gamma
-
 Sus scrofa
PIP5Kgamma
-
 Homo sapiens
PIP5Kgamma
-
 Sus scrofa

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens
ATP
-
 Sus scrofa

General Information

General Information Comment Organism
physiological function phosphatidylinositol 4,5 bisphosphate is a major membrane phospholipid that affects cellular processes such as actin cytoskeleton modulation, membrane trafficking and ion channel activity. Isozyme PIP5Kgamma is essential for advanced glycation end products induced inhibition of renal Na+/K+ ATPase activity Homo sapiens
physiological function phosphatidylinositol 4,5 bisphosphate is a major membrane phospholipid that affects cellular processes such as actin cytoskeleton modulation, membrane trafficking and ion channel activity. Isozyme PIP5Kgamma is essential for advanced glycation end products induced inhibition of renal Na+/K+ ATPase activity Sus scrofa