Literature summary for 2.7.1.68 extracted from

Halstead, J.R.; van Rheenen, J.; Snel, M.H.; Meeuws, S.; Mohammed, S.; DSantos, C.S.; Heck, A.J.; Jalink, K.; Divecha, N.
A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis (2006), Curr. Biol., 16, 1850-1856.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in HeLa cells	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
H2O2	the enzyme is inhibited after 20 min incubation with 0.6 mM H2O2	Homo sapiens
H2O2	the enzyme is inhibited after 20 min incubation with 0.6 mM H2O2	Mus musculus
additional information	not inhibited by SP600125, SB203580, ZVAD-fmk, wortmannin or LY294002	Homo sapiens
additional information	not inhibited by SP600125, SB203580, ZVAD-fmk, wortmannin or LY294002	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
plasma membrane	-	Mus musculus	5886	-
plasma membrane	-	Homo sapiens	5886	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate	-	Mus musculus	ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate	-	?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate	-	Homo sapiens	ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate	-	?

Synonyms

Synonyms	Comment	Organism
PIP5Kalpha	-	Mus musculus
PIP5Kbeta	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Mus musculus
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)