Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | enzyme form 10 is insensitive to phosphatidic acid | Arabidopsis thaliana | |
phosphatidic acid | activates enzyme form 1 by 2.1fold | Arabidopsis thaliana | |
phosphatidic acid | activates isozyme alpha by 2.0fold | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of enzyme form 1 as GST-fusion protein in Escherichia coli, expression of His-tagged enzyme form 1 in Spodoptera frugiperda Sf9 cells via baculovirus infection system | Arabidopsis thaliana |
expression of enzyme form 10 as GST-fusion protein in Escherichia coli, expression of His-tagged enzyme form 10 in Spodoptera frugiperda Sf9 cells via baculovirus infection system | Arabidopsis thaliana |
expression of isozyme alpha as GST-fusion protein in Escherichia coli | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.065 | - |
1-phosphatidyl-1D-myo-inositol 4-phosphate | recombinant enzyme form 10 | Arabidopsis thaliana | |
0.6 | - |
1-phosphatidyl-1D-myo-inositol 4-phosphate | recombinant enzyme form 1 | Arabidopsis thaliana | |
4.1 | - |
1-phosphatidyl-1D-myo-inositol 4-phosphate | recombinant isozyme alpha | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Arabidopsis thaliana | |
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | Arabidopsis thaliana | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | Homo sapiens | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | Q56YP2 | enzyme form 1; enzyme form 1 | - |
Arabidopsis thaliana | Q9LMN1 | enzyme form 10; enzyme form 10 | - |
Homo sapiens | Q99755 | isozyme alpha type I; type I isozyme alpha | - |
Purification (Comment) | Organism |
---|---|
recombinan GST-fusion isozyme alpha from Escherichia coli | Homo sapiens |
recombinant GST-fusion protein from Escherichia coli in presence of Triton X-100 and PtdOH | Arabidopsis thaliana |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
flower | enzyme form 10, most abundant in | Arabidopsis thaliana | - |
inflorescence stalk | enzyme form 10, most abundant in | Arabidopsis thaliana | - |
additional information | tissue distribution | Arabidopsis thaliana | - |
additional information | tissue distribution, enzyme form 1 is present in all tissues | Arabidopsis thaliana | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
enzyme form 10 shows 10fold lower activity than enzyme form 1 in recombinant Sf9 cells, overview | Arabidopsis thaliana |
additional information | - |
recombinant isozyme alpha | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
Arabidopsis thaliana | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | phosphatidylinositol phosphate 5-kinase 1 belongs to the subfamily B | Arabidopsis thaliana |
More | phosphatidylinositol phosphate 5-kinase 10 belongs to the subfamily A | Arabidopsis thaliana |
phosphatidylinositol phosphate 5-kinase 1 | - |
Arabidopsis thaliana |
phosphatidylinositol phosphate 5-kinase 10 | - |
Arabidopsis thaliana |
PIPK1 | - |
Arabidopsis thaliana |
PIPK10 | - |
Arabidopsis thaliana |
PIPKIalpha | - |
Homo sapiens |
PtdInsP | - |
Arabidopsis thaliana |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Arabidopsis thaliana | |
ATP | - |
Homo sapiens |