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Literature summary for 2.7.1.68 extracted from

  • Perera, I.Y.; Davis, A.J.; Galanopoulou, D.; Im, Y.J.; Boss, W.F.
    Characterization and comparative analysis of Arabidopsis phosphatidylinositol phosphate 5-kinase 10 reveals differences in Arabidopsis and human phosphatidylinositol phosphate kinases (2005), FEBS Lett., 579, 3427-3432.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information enzyme form 10 is insensitive to phosphatidic acid Arabidopsis thaliana
phosphatidic acid activates enzyme form 1 by 2.1fold Arabidopsis thaliana
phosphatidic acid activates isozyme alpha by 2.0fold Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of enzyme form 1 as GST-fusion protein in Escherichia coli, expression of His-tagged enzyme form 1 in Spodoptera frugiperda Sf9 cells via baculovirus infection system Arabidopsis thaliana
expression of enzyme form 10 as GST-fusion protein in Escherichia coli, expression of His-tagged enzyme form 10 in Spodoptera frugiperda Sf9 cells via baculovirus infection system Arabidopsis thaliana
expression of isozyme alpha as GST-fusion protein in Escherichia coli Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.065
-
1-phosphatidyl-1D-myo-inositol 4-phosphate recombinant enzyme form 10 Arabidopsis thaliana
0.6
-
1-phosphatidyl-1D-myo-inositol 4-phosphate recombinant enzyme form 1 Arabidopsis thaliana
4.1
-
1-phosphatidyl-1D-myo-inositol 4-phosphate recombinant isozyme alpha Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Arabidopsis thaliana
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Arabidopsis thaliana
-
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Homo sapiens
-
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q56YP2 enzyme form 1; enzyme form 1
-
Arabidopsis thaliana Q9LMN1 enzyme form 10; enzyme form 10
-
Homo sapiens Q99755 isozyme alpha type I; type I isozyme alpha
-

Purification (Commentary)

Purification (Comment) Organism
recombinan GST-fusion isozyme alpha from Escherichia coli Homo sapiens
recombinant GST-fusion protein from Escherichia coli in presence of Triton X-100 and PtdOH Arabidopsis thaliana

Source Tissue

Source Tissue Comment Organism Textmining
flower enzyme form 10, most abundant in Arabidopsis thaliana
-
inflorescence stalk enzyme form 10, most abundant in Arabidopsis thaliana
-
additional information tissue distribution Arabidopsis thaliana
-
additional information tissue distribution, enzyme form 1 is present in all tissues Arabidopsis thaliana
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
enzyme form 10 shows 10fold lower activity than enzyme form 1 in recombinant Sf9 cells, overview Arabidopsis thaliana
additional information
-
recombinant isozyme alpha Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
Arabidopsis thaliana ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
?

Synonyms

Synonyms Comment Organism
More phosphatidylinositol phosphate 5-kinase 1 belongs to the subfamily B Arabidopsis thaliana
More phosphatidylinositol phosphate 5-kinase 10 belongs to the subfamily A Arabidopsis thaliana
phosphatidylinositol phosphate 5-kinase 1
-
Arabidopsis thaliana
phosphatidylinositol phosphate 5-kinase 10
-
Arabidopsis thaliana
PIPK1
-
Arabidopsis thaliana
PIPK10
-
Arabidopsis thaliana
PIPKIalpha
-
Homo sapiens
PtdInsP
-
Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
ATP
-
Arabidopsis thaliana
ATP
-
Homo sapiens