Any feedback?
Literature summary for 2.7.1.68 extracted from
- Regulation and cellular roles of phosphoinositide 5-kinases (2004), Eur. J. Pharmacol., 500, 87-99.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| lysophosphatidic acid | - |
Saccharomyces cerevisiae |  |
| lysophosphatidic acid | - |
Schizosaccharomyces pombe | |
| lysophosphatidic acid | - |
Candida albicans | |
| lysophosphatidic acid | mechanism overview | Mus musculus | |
| lysophosphatidic acid | mechanism overview | Homo sapiens | |
| small GTPase Arf | - |
Saccharomyces cerevisiae | |
| small GTPase Arf | - |
Schizosaccharomyces pombe | |
| small GTPase Arf | - |
Candida albicans | |
| small GTPase Arf | involved in membrane receptor-mediated regulation, acts via effectors, mechanism overview | Mus musculus | |
| small GTPase Arf | involved in membrane receptor-mediated regulation, acts via effectors, mechanism overview | Homo sapiens | |
| small GTPase Rho | - |
Saccharomyces cerevisiae | |
| small GTPase Rho | - |
Schizosaccharomyces pombe | |
| small GTPase Rho | - |
Candida albicans | |
| small GTPase Rho | involved in membrane receptor-mediated regulation, acts via effectors, mechanism overview | Mus musculus | |
| small GTPase Rho | involved in membrane receptor-mediated regulation, acts via effectors, mechanism overview | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | associated | Saccharomyces cerevisiae | 16020 | - |
| membrane | associated | Candida albicans | 16020 | - |
| additional information | subcellular localization of isozymes is regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, overview | Candida albicans | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Mus musculus | |
| Mg2+ | - |
Homo sapiens | |
| Mg2+ | - |
Saccharomyces cerevisiae | |
| Mg2+ | - |
Schizosaccharomyces pombe | |
| Mg2+ | - |
Candida albicans | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 68000 | - |
x * 68000, isozymes alpha or beta, x * 90000, isozyme gamma | Mus musculus |
| 68000 | - |
x * 68000, isozymes alpha or beta, x * 90000, isozyme gamma | Homo sapiens |
| 90000 | - |
x * 68000, isozymes alpha or beta, x * 90000, isozyme gamma | Mus musculus |
| 90000 | - |
x * 68000, isozymes alpha or beta, x * 90000, isozyme gamma | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | Mus musculus | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | Homo sapiens | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | Saccharomyces cerevisiae | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | Schizosaccharomyces pombe | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | Candida albicans | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, in gene expression and cell survival, and in establishment of cell morphology and during temperature-induced hyphal growth, respectively, overview | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
| additional information | Candida albicans | activities of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview | ? | - |
? | |
| additional information | Mus musculus | subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview | ? | - |
? | |
| additional information | Homo sapiens | subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview | ? | - |
? | |
| additional information | Saccharomyces cerevisiae | subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview | ? | - |
? | |
| additional information | Schizosaccharomyces pombe | subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Candida albicans | - |
- |
- |
| Homo sapiens | - |
enzyme form type I, 3 isozymes alpha, beta, gamma in several splicing variants | - |
| Mus musculus | - |
enzyme form type I, 3 isozymes alpha, beta, gamma in several splicing variants | - |
| Saccharomyces cerevisiae | - |
- |
- |
| Schizosaccharomyces pombe | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | the enzyme is negatively regulated by, besides other mechanisms, phosphorylation by casein kinase I | Schizosaccharomyces pombe |
| phosphoprotein | the enzyme is negatively regulated by, besides other mechanisms, phosphorylation, autophosphorylation is enhanced by phosphatidylinositol | Saccharomyces cerevisiae |
| phosphoprotein | the enzyme is negatively regulated by, besides other mechanisms, phosphorylation, autophosphorylation is enhanced by phosphatidylinositol | Candida albicans |
| phosphoprotein | the enzyme is negatively regulated by, besides other mechanisms, phosphorylation, autophosphorylation is enhanced by phosphatidylinositol, Ca2+ induces dephosphorylation of isozyme gamma at serine 264, phosphorylation by 9,11-dideoxy-9alpha,11alpha-methanoepoxyprostaglandin U46619 is inhibited by genistein in platelets, tyrosine phosphorylation by focal adhesion kinase of isozyme gamma brain splice variant associated to the FERM domain of talin in brain | Homo sapiens |
| phosphoprotein | the enzyme is negatively regulated by, besides other mechanisms, phosphorylation, autophosphorylation is enhanced by phosphatidylinositol, isozyme alpha is phosphorylated by cAMP-dependent protein kinase at serine 214, Ca2+ induces dephosphorylation of isozyme gamma at serine 264, phosphorylation by 9,11-dideoxy-9alpha,11alpha-methanoepoxyprostaglandin U46619 is inhibited by genistein in platelets, tyrosine phosphorylation by focal adhesion kinase of isozyme gamma brain splice variant associated to the FERM domain of talin in brain | Mus musculus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | an activation loop spanning the catalytic domain is responsible for determination of both substrate specificity and subcellular targeting | Mus musculus | |
| ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | an activation loop spanning the catalytic domain is responsible for determination of both substrate specificity and subcellular targeting | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood platelet | - |
Mus musculus | - |
| blood platelet | - |
Homo sapiens | - |
| brain | - |
Mus musculus | - |
| brain | - |
Homo sapiens | - |
| erythrocyte | - |
Mus musculus | - |
| erythrocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
Mus musculus | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
Saccharomyces cerevisiae | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
Schizosaccharomyces pombe | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
Candida albicans | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview | Mus musculus | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview | Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview | Saccharomyces cerevisiae | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview | Schizosaccharomyces pombe | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, in gene expression and cell survival, and in establishment of cell morphology and during temperature-induced hyphal growth, respectively, overview | Candida albicans | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
| additional information | activities of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview | Candida albicans | ? | - |
? | |
| additional information | subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview | Mus musculus | ? | - |
? | |
| additional information | subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview | Homo sapiens | ? | - |
? | |
| additional information | subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview | Saccharomyces cerevisiae | ? | - |
? | |
| additional information | subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview | Schizosaccharomyces pombe | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 68000, isozymes alpha or beta, x * 90000, isozyme gamma | Mus musculus |
| ? | x * 68000, isozymes alpha or beta, x * 90000, isozyme gamma | Homo sapiens |
| More | 2 dimerization domains may be involved in subcellular targeting in isozyme beta | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MSS4p | - |
Saccharomyces cerevisiae |
| MSS4p | - |
Candida albicans |
| phosphatidylinositol 4-phosphate 5-kinase | - |
Mus musculus |
| phosphatidylinositol 4-phosphate 5-kinase | - |
Homo sapiens |
| phosphatidylinositol 4-phosphate 5-kinase | - |
Saccharomyces cerevisiae |
| phosphatidylinositol 4-phosphate 5-kinase | - |
Schizosaccharomyces pombe |
| phosphatidylinositol 4-phosphate 5-kinase | - |
Candida albicans |
| PIP5K type I | - |
Mus musculus |
| PIP5K type I | - |
Homo sapiens |
| PIP5K type I | - |
Saccharomyces cerevisiae |
| PIP5K type I | - |
Schizosaccharomyces pombe |
| PIP5K type I | - |
Candida albicans |
| PIP5KI | - |
Mus musculus |
| PIP5KI | - |
Homo sapiens |
| PIP5KI | - |
Saccharomyces cerevisiae |
| PIP5KI | - |
Schizosaccharomyces pombe |
| PIP5KI | - |
Candida albicans |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
| ATP | - |
Homo sapiens | |
| ATP | - |
Saccharomyces cerevisiae | |
| ATP | - |
Schizosaccharomyces pombe | |
| ATP | - |
Candida albicans | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
