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Literature summary for 2.7.1.68 extracted from

  • Zhang, X.; Loijens, J.C.; Boronenkov, I.V.; Parker, G.J.; Norris, F.A.; Chen, J.; Thum, O.; Prestwich, G.D.; Majerus, P.W.; Anderson, R.A.
    Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules (1997), J. Biol. Chem., 272, 17756-17761.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression in COS cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.005
-
 1-phosphatidyl-1D-myo-inositol 3-phosphate pH 7.5, enzyme type Ibeta Homo sapiens
0.006
-
 phosphatidylinositol 3,4-bisphosphate pH 7.5, enzyme type Ibeta Homo sapiens
0.047
-
 1-phosphatidyl-1D-myo-inositol 4-phosphate pH 7.5, enzyme type Ialpha Homo sapiens
0.05
-
 1-phosphatidyl-1D-myo-inositol 4-phosphate pH 7.5, enzyme type IIalpha Homo sapiens
0.065
-
 1-phosphatidyl-1D-myo-inositol 3-phosphate pH 7.5, enzyme type Ialpha Homo sapiens
0.08
-
 phosphatidylinositol 3,4-bisphosphate pH 7.5, enzyme type IIalpha Homo sapiens
0.12
-
 phosphatidylinositol 3-phosphate pH 7.5, enzyme type IIalpha Homo sapiens
0.262
-
 1-phosphatidyl-1D-myo-inositol 4-phosphate pH 7.5, enzyme type Ibeta Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
ATP + phosphatidylinositol 3-phosphate
-
 Homo sapiens ADP + phosphatidylinositol 3,4-bisphosphate
-
 ?
ATP + phosphatidylinsositol 3,4-bisphosphate
-
 Homo sapiens ADP + phosphatidylinositol 3,4,5-trisphosphate
-
 ?