Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | 0.3 mM, 50% inhibition. Increasing Mg2+ concentrations antagonize this inhibition | Bos taurus | |
phosphatidylinositol 4,5-bisphosphate | 0.5 mg/ml, 59% inhibition | Bos taurus | |
phosphatidylinositol 4-phosphate | 0.5 mg/ml, 42% inhibition | Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.018 | - |
ATP | pH 7.0, 30°C | Bos taurus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | activates, maximal activity at 2-10 mM | Bos taurus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
55000 | - |
1 * 55000, SDS-PAGE | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
uterus | - |
Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
2.7 | - |
- |
Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + 1-phosphatidyl-1D-myo-inositol | 12% of the activity with ATP | Bos taurus | AMP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
ATP + 1-phosphatidyl-1D-myo-inositol | - |
Bos taurus | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
CTP + 1-phosphatidyl-1D-myo-inositol | 10% of the activity with ATP | Bos taurus | CDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
dATP + 1-phosphatidyl-1D-myo-inositol | 104% of the activity with ATP | Bos taurus | dADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
GTP + 1-phosphatidyl-1D-myo-inositol | 5% of the activity with ATP | Bos taurus | GDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
ITP + 1-phosphatidyl-1D-myo-inositol | 11% of the activity with ATP | Bos taurus | IDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
TTP + 1-phosphatidyl-1D-myo-inositol | 3% of the activity with ATP | Bos taurus | TDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
UTP + 1-phosphatidyl-1D-myo-inositol | 18% of the activity with ATP | Bos taurus | UDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 55000, SDS-PAGE | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | 7 | - |
Bos taurus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5 | 8 | pH 5.0: about 40% of maximal activity, pH 8.0: about 50% of maximal activity | Bos taurus |