Activating Compound | Comment | Organism | Structure |
---|---|---|---|
(1S,2S)-3-(2-hydroxy-4-methoxyphenyl)-1-(4-methoxyphenyl)propane-1,2-diol | AC50 value of 0.15 mM | Homo sapiens | |
(2R,3S)-2-phenyl-3,4-dihydro-2H-chromen-3-ol | AC50 value of 0.221 mM | Homo sapiens | |
(2R,3S)-5,7-diphenoxy-2-(3,4,5-triphenoxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-ol | AC50 value of 0.028 mM | Homo sapiens | |
(3S)-7-phenoxy-2-(4-phenoxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-ol | AC50 value of 0.115 mM | Homo sapiens | |
(3S,4S)-2-(3,4-diphenoxyphenyl)-5,7-diphenoxy-3,4-dihydro-2H-1-benzopyran-3,4-diol | AC50 value of 0.048 mM | Homo sapiens | |
3-(2-hydroxy-4-phenoxyphenyl)-1-(4-phenoxyphenyl)propane-1,2-diol | AC50 value of 0.2 mM | Homo sapiens | |
5-methoxy-2-[(2E)-3-(4-methoxyphenyl)prop-2-en-1-yl]phenol | AC50 value of 0.027 mM | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E)-1-(4-methoxyphenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one | - |
Homo sapiens | |
(2R,3S)-2-(3,4-diphenoxyphenyl)-3,5,7-triphenoxy-3,4-dihydro-2H-1-benzopyran | - |
Homo sapiens | |
3,5-diphenoxy-2-[(2E)-3-(3,4,5-triphenoxyphenyl)prop-2-en-1-yl]phenol | - |
Homo sapiens | |
3-(2-hydroxy-4-methoxyphenyl)-1-(4-methoxyphenyl)propane-1,2-diol | - |
Homo sapiens | |
5,7-diphenoxy-2-(3,4,5-triphenoxyphenyl)-2H-1-benzopyran | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + pyruvate | Homo sapiens | - |
ADP + phosphoenolpyruvate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + pyruvate | - |
Homo sapiens | ADP + phosphoenolpyruvate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PKM2 | - |
Homo sapiens |
pyruvate kinase isoenzyme M2 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.045 | - |
at pH 8.0 and 22°C | Homo sapiens | 5,7-diphenoxy-2-(3,4,5-triphenoxyphenyl)-2H-1-benzopyran | |
0.058 | - |
at pH 8.0 and 22°C | Homo sapiens | (2R,3S)-2-(3,4-diphenoxyphenyl)-3,5,7-triphenoxy-3,4-dihydro-2H-1-benzopyran | |
0.145 | - |
at pH 8.0 and 22°C | Homo sapiens | 3,5-diphenoxy-2-[(2E)-3-(3,4,5-triphenoxyphenyl)prop-2-en-1-yl]phenol | |
0.163 | - |
at pH 8.0 and 22°C | Homo sapiens | (2E)-1-(4-methoxyphenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one | |
0.295 | - |
at pH 8.0 and 22°C | Homo sapiens | 3-(2-hydroxy-4-methoxyphenyl)-1-(4-methoxyphenyl)propane-1,2-diol |
General Information | Comment | Organism |
---|---|---|
metabolism | pyruvate kinase isoenzyme M2 plays an important role in the control of glucose metabolism | Homo sapiens |