Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.40 extracted from

  • Solomons, J.T.; Johnsen, U.; Schönheit, P.; Davies, C.
    3-Phosphoglycerate is an allosteric activator of pyruvate kinase from the hyperthermophilic archaeon Pyrobaculum aerophilum (2013), Biochemistry, 52, 5865-5875.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
3-phosphoglycerate allosteric activator. Regulation of the enzyme by a carboxylate molecule rather than a sugar phosphate may reflect a step in the evolution of glycolysis that predates the dominance of sugars in metabolism Pyrobaculum aerophilum

Cloned(Commentary)

Cloned (Comment) Organism
-
Pyrobaculum aerophilum

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging-drop vapor diffusion method at 18°C, crystal structure is determined to 2.2 A resolution Pyrobaculum aerophilum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + pyruvate Pyrobaculum aerophilum the enzyme catalyzes the final step of glycolysis ADP + phosphoenolpyruvate
-
?
ATP + pyruvate Pyrobaculum aerophilum DSM 7523 the enzyme catalyzes the final step of glycolysis ADP + phosphoenolpyruvate
-
?

Organism

Organism UniProt Comment Textmining
Pyrobaculum aerophilum Q8ZYE0
-
-
Pyrobaculum aerophilum DSM 7523 Q8ZYE0
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Pyrobaculum aerophilum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + pyruvate
-
Pyrobaculum aerophilum ADP + phosphoenolpyruvate
-
?
ATP + pyruvate the enzyme catalyzes the final step of glycolysis Pyrobaculum aerophilum ADP + phosphoenolpyruvate
-
?
ATP + pyruvate
-
Pyrobaculum aerophilum DSM 7523 ADP + phosphoenolpyruvate
-
?
ATP + pyruvate the enzyme catalyzes the final step of glycolysis Pyrobaculum aerophilum DSM 7523 ADP + phosphoenolpyruvate
-
?

Synonyms

Synonyms Comment Organism
PAE0819 locus name Pyrobaculum aerophilum

General Information

General Information Comment Organism
physiological function the enzyme catalyzes the final step of glycolysis Pyrobaculum aerophilum