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Literature summary for 2.7.1.40 extracted from

  • Fenton, A.W.; Hutchinson, M.
    The pH dependence of the allosteric response of human liver pyruvate kinase to fructose-1,6-bisphosphate, ATP, and alanine (2009), Arch. Biochem. Biophys., 484, 16-23.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.40

Activating Compound

Activating Compound Comment Organism Structure
D-fructose 1,6-bisphosphate the smallest allosteric response to D-fructose 1,6-bisphosphate occurs at pH 6.5 and increases up to pH 8.0 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli FF50 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ATP as pH increases (pH range 6.5-8.0), ATP elicits more inhibition Homo sapiens
L-Ala
-
 Homo sapiens
phosphoenolpyruvate at 5°C, concentrations greater than 10 mM are inhibiting Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate precipitation, DEAE-cellulose column chromatography and Superdex S-200 gel filtration Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphoenolpyruvate as a function of increasing pH (pH 6.5-8.0), PYK's affinity for phosphoenolpyruvate decreases, while affinity for ATP slightly increases Homo sapiens ATP + pyruvate
-
 ?

Synonyms

Synonyms Comment Organism
PYK
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ADP
-
 Homo sapiens