Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.40 extracted from

  • Dombrauckas, J.D.; Santarsiero, B.D.; Mesecar, A.D.
    Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis (2005), Biochemistry, 44, 9417-9429.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
D-fructose 1,6-bisphosphate activates Homo sapiens

Application

Application Comment Organism
diagnostics its presence in human plasma is currently being used as a molecular marker for the diagnosis of various cancers Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
the X-ray structure of human hPKM2 complexed with Mg2+, K+, the inhibitor oxalate, and the allosteric activator D-fructose 1,6-bisphosphate determined to a resolution of 2.82 A. (His)6-tagged hPKM2 complex, hanging drop vapor diffusion Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.17
-
phosphoenolpyruvate pH 8.0, 32°C, activation by 2 mM D-fructose-1,6-bisphosphate Homo sapiens
0.24
-
ADP pH 8.0, 32°C, activation by 2 mM D-fructose-1,6-bisphosphate Homo sapiens
0.34
-
ADP pH 8.0, 32°C Homo sapiens
2.1
-
phosphoenolpyruvate pH 8.0, 32°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P14618
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphoenolpyruvate
-
Homo sapiens ATP + pyruvate
-
?

Synonyms

Synonyms Comment Organism
hPKM2 pyruvate kinase isoenzyme M2 Homo sapiens