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Literature summary for 2.7.1.32 extracted from

  • Schiaffino-Ortega, S.; Lopez-Cara, L.C.; Rios-Marco, P.; Carrasco-Jimenez, M.P.; Gallo, M.A.; Espinosa, A.; Marco, C.; Entrena, A.
    New non-symmetrical choline kinase inhibitors (2013), Bioorg. Med. Chem., 21, 7146-7154.
    View publication on PubMed
Search for more literature for 2.7.1.32

Inhibitors

Inhibitors Comment Organism Structure
1-(4-(4-[(3-aminophenoxy)methyl]phenethyl)benzyl)-4-(dimethylamino)pyridinium bromide 21.9% inhibition at 0.05 mM Homo sapiens
1-(4-[4-[(3-hydroxyphenylamino)methyl]phenethyl]-benzyl)-4-(pyrrolidin-1-yl)pyridinium bromide 13.6% inhibition at 0.05 mM Homo sapiens
1-([4'-[(3-aminophenoxy)methyl]biphenyl-4-yl]methyl)-4-(dimethylamino)pyridinium bromide 79.8% inhibition at 0.05 mM Homo sapiens
1-([4'-[(3-aminophenoxy)methyl]biphenyl-4-yl]methyl)-4-(pyrrolidin-1-yl)pyridinium bromide 20.8% inhibition at 0.05 mM Homo sapiens
1-([4'-[(3-hydroxyphenylamino)methyl]biphenyl-4-yl]-methyl)-4-(pyrrolidin-1-yl)-pyridinium bromide 28.2% inhibition at 0.05 mM Homo sapiens
1-[4-(4-[4-[(3-aminophenoxy)methyl]phenyl]butyl)-benzyl]-4-(pyrrolidin-1-yl)pyridinium bromide 21.6% inhibition at 0.05 mM Homo sapiens
1-[4-(4-[4-[(3-hydroxyphenylamino)methyl]phenyl]-butyl)benzyl]-4-(pyrrolidin-1-yl)pyridinium bromide 18% inhibition at 0.05 mM Homo sapiens
1-[4-[(3-aminophenoxy)methyl]benzyl]-4-(dimethylamino)pyridinium bromide 37.7% inhibition at 0.05 mM Homo sapiens
1-[4-[(3-aminophenoxy)methyl]benzyl]-4-(pyrrolidin-1-yl)pyridinium bromide 12.9% inhibition at 0.05 mM Homo sapiens
1-[4-[(3-hydroxyphenylamino)methyl]benzyl]-4-(pyrrolidin-1-yl)pyridinium bromide 41.3% inhibition at 0.05 mM Homo sapiens
4-(dimethylamino)-1-(4-(3-(4-(((3-hydroxyphenyl)amino)methyl)phenyl)propyl)benzyl)pyridin-1-ium bromide 12.9% inhibition at 0.05 mM Homo sapiens
4-(dimethylamino)-1-(4-(4-(((3-hydroxyphenyl)amino)methyl)benzyl)benzyl)pyridin-1-ium bromide 39.5% inhibition at 0.05 mM Homo sapiens
4-(dimethylamino)-1-({4-[(3-hydroxyphenylamino)-methyl]biphenyl-4-yl}methyl)pyridinium bromide 66.2% inhibition at 0.05 mM Homo sapiens
4-(dimethylamino)-1-[4-[(3-hydroxyphenylamino)-methyl]benzyl]pyridinium bromide 52.4% inhibition at 0.05 mM Homo sapiens
hemicolinium
-
 Homo sapiens
additional information not inhibited by 1-[4-(4-[4-[(3-aminophenoxy)methyl]phenyl]butyl)-benzyl]-4-(dimethylamino)pyridinium bromide Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + choline Homo sapiens
-
 ADP + phosphocholine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P35790
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + choline
-
 Homo sapiens ADP + phosphocholine
-
 ?

Synonyms

Synonyms Comment Organism
ATP/choline phosphotransferase
-
 Homo sapiens
CHOKalpha1 isoform Homo sapiens