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Literature summary for 2.7.1.32 extracted from

  • Miyake, T.; Parsons, S.J.
    Functional interactions between choline kinase alpha, epidermal growth factor receptor and c-Src in breast cancer cell proliferation (2012), Oncogene, 31, 1431-1441.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.32

Activating Compound

Activating Compound Comment Organism Structure
c-Src isoform CHKA2 total cellular activity and protein levels are regulated by c-Src Homo sapiens
epidermal growth factor receptor isoform CHKA2 total cellular activity and protein levels are regulated by epidermal growth factor receptor. In the presence of co-transfected epidermal growth factor receptor, the activity of wild type isoform CHKA2 is increased 2.5 fold Homo sapiens

Protein Variants

Protein Variants Comment Organism
D306A inactive Homo sapiens
Y197/333F the mutant shows reduced activity in the presence of epidermal growth factor receptor compared to the wild type enzyme Homo sapiens
Y197F the mutant shows reduced activity in the presence of epidermal growth factor receptor compared to the wild type enzyme Homo sapiens
Y333F the mutant shows reduced activity in the presence of epidermal growth factor receptor compared to the wild type enzyme Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P35790
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-
HEK-293T cell
-
 Homo sapiens
-
MCF-10A cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + choline
-
 Homo sapiens ADP + phosphocholine
-
 ?

Synonyms

Synonyms Comment Organism
Chka
-
 Homo sapiens
CHKA2 isoform Homo sapiens
choline kinase alpha
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme knockdown in MCF-7 and MCF-10A cells reduces epidermal growth factor-dependent cell proliferation Homo sapiens
physiological function the enzyme is required for maximum epidermal growth factor-dependent cell growth in mammary epithelium-derived cell lines MCF-7 and MCF-10A Homo sapiens