Literature summary for 2.7.1.32 extracted from

Gallego-Ortega, D.; Ramirez de Molina, A.; Ramos, M.A.; Valdes-Mora, F.; Barderas, M.G.; Sarmentero-Estrada, J.; Lacal, J.C.
Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment (2009), PLoS ONE, 4, e7819.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
choline kinase inhibitor Mn58b	-	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.2	-	choline	-	Homo sapiens
0.57	-	choline	-	Homo sapiens
2.01	-	ethanolamine	-	Homo sapiens
12.01	-	ethanolamine	-	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
45000	-	2 * 45000, Western Blot analysis	Homo sapiens
50000	-	2 * 50000, Western Blot analysis	Homo sapiens
52000	-	2 * 52000, Western Blot analysis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P35790	-	-
Homo sapiens	Q9Y259	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
choline + ATP	-	Homo sapiens	phosphocholine + ADP	-	?
ethanolamine + ATP	-	Homo sapiens	phosphoethanolamine + ADP	-	?

Subunits

Subunits	Comment	Organism
homodimer	2 * 45000, Western Blot analysis	Homo sapiens
homodimer	2 * 50000, Western Blot analysis	Homo sapiens
homodimer	2 * 52000, Western Blot analysis	Homo sapiens

Synonyms

Synonyms	Comment	Organism
choline kinase alpha1	-	Homo sapiens
choline kinase alpha2	-	Homo sapiens
choline kinase beta1	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.005	-	-	Homo sapiens	choline kinase inhibitor Mn58b
0.1075	-	-	Homo sapiens	choline kinase inhibitor Mn58b

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Release 2023.1 (January 2023)