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Literature summary for 2.7.1.21 extracted from

  • Chen, Y.L.; Eriksson, S.; Chang, Z.F.
    Regulation and functional contribution of thymidine kinase 1 in repair of DNA damage (2010), J. Biol. Chem., 285, 27327-27335.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.21

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
H-1299 cell
-
 Homo sapiens
-
HCT-116 cell
-
 Homo sapiens
-
SW-480 cell
-
 Homo sapiens
-
U2-OS cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + thymidine
-
 Homo sapiens ADP + dTMP
-
 ?

Synonyms

Synonyms Comment Organism
thymidine kinase 1
-
 Homo sapiens
TK1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens DNA damage causes up-regulation of thymidine kinase 1 in tumor cells up

General Information

General Information Comment Organism
malfunction depletion of thymidine kinase 1 decreases the efficiency of DNA repair during recovery from DNA damage and generates more cell death Homo sapiens
physiological function thymidine kinase 1 C´contributes to the increase in dTTP pool during recovery from DNA damage and affects the efficiency of DNA repair during recovery for G2/M progression Homo sapiens