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Literature summary for 2.7.1.21 extracted from
- Selective abolishment of pyrimidine nucleoside kinase activity of herpes simplex virus type 1 thymidine kinase by mutation of alanine-167 to tyrosine (2000), Mol. Pharmacol., 58, 1326-1332.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Herpes simplex virus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| A167Y | heavily reduced ability to phosphorylate pyrimidine nucleosides, ability to phosphorylate ganciclovir and lobucavir is reduced 2fold | Herpes simplex virus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Herpes simplex virus | - |
type 1 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| wild-type and A167Y mutant | Herpes simplex virus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + ganciclovir | - |
Herpes simplex virus | ? | - |
? |  |
| ATP + lobucavir | - |
Herpes simplex virus | ? | - |
? | |
| ATP + thymidine | - |
Herpes simplex virus | ADP + dTMP | - |
? | |
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Release 2023.1 (January 2023)
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