Cloned (Comment) | Organism |
---|---|
gene PIK3C2B, quantitative expression analysis | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | enzyme downregulation by specific shRNA in MCF-7, T-47D, and MDA-MB-231 cancer cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00750 | gene PIK3C2B | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BRE-80 cell | - |
Homo sapiens | - |
breast | non-neoplastic breast tissues | Homo sapiens | - |
breast cancer cell | isozyme PI3K-C2beta is overexpressed in human breast cancer cell lines | Homo sapiens | - |
HBL-100 cell | - |
Homo sapiens | - |
lymph node | PI3K-C2beta is highly expressed in lymph-nodes metastases compared to matching primary tumors | Homo sapiens | - |
MCF-10A cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
T-47D cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
class II phosphoinositide 3-kinase C2beta | - |
Homo sapiens |
PI3K-C2beta | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | downregulation of PI3K-C2beta in breast cancer cell lines reduces colony formation, induces cell cycle arrest and inhibits tumor growth, in particular in an estrogen-dependent in vivo xenograft. PI3K-C2beta inhibits breast cancer cell invasion in vitro and breast cancer metastasis in vivo | Homo sapiens |
physiological function | class II phosphoinositide 3-kinase C2beta regulates a novel signaling pathway involved in breast cancer progression. Isozyme PI3K-C2beta regulates breast cancer cell growth in vitro and in vivo, PI3K-C2beta expression in breast tissues is correlated with the proliferative status of the tumor. Analsis of the mechanism of the PI3K-C2beta-dependent regulation of cell cycle progression and cell growth revealed that PI3K-C2beta regulates cyclin B1 protein levels through modulation of microRNA miR-449a levels. PI3K-C2beta may represent a key molecular switch that regulates a rate-limiting step in breast tumor progression and therefore it may be targeted to limit breast cancer spread. PI3K-C2beta regulates cyclin B1 expression through modulation of miR-449a, miR-449a levels are downregulated in primary human breast cancer samples, and cyclin B1/miR-449a expression through modulation of LEF1/beta catenin pathway in MDA-MB-231 cells. PI3K-C2beta regulates senescence via miR-449 regulation | Homo sapiens |