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Literature summary for 2.7.1.154 extracted from

  • Aki, S.; Yoshioka, K.; Okamoto, Y.; Takuwa, N.; Takuwa, Y.
    Phosphatidylinositol 3-kinase class II alpha-isoform PI3K-C2alpha is required for transforming growth factor beta-induced Smad signaling in endothelial cells (2015), J. Biol. Chem., 290, 6086-6105.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.154

Protein Variants

Protein Variants Comment Organism
additional information knockdown of PI3K-C2alpha by specific siRNA in human umbilical vein endothelial cells Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Homo sapiens
-
 ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O00443 subunit alpha; gene PIK3C2A
-

Source Tissue

Source Tissue Comment Organism Textmining
umbilical vein endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
class II PI3K-C2alpha
-
 Homo sapiens
phosphatidylinositol 3-kinase class II alpha
-
 Homo sapiens
PI3K-C2alpha
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction TGFbeta1 stimulated nuclear accumulation of p-Smad2 is markedly suppressed by PI3K-C2alpha knockdown. Effect of PI3K-C2alpha knockdown on the co-localization of TGFbeta1 receptors and SARA. PI3K-C2alpha knockdown does not affect the numbers of either SARA-positive or EEA1-positive vesicles in nonstimulated cells but abolished TGFbeta1-induced increase in SARA- and EEA1-double positive early endosomes Homo sapiens
physiological function isozyme phosphatidylinositol 3-kinase class II alpha is required for transforming growth factor beta-induced Smad signaling in endothelial cells, but not in smooth muscle cells or epithelial cells. TGFbeta1-induced phosphorylation and nuclear translocation of Smad2/3 are dependent on class II PI3K-C2alpha. C2alpha is required for SARA-Smad2/3 complex formation Homo sapiens