Literature summary for 2.7.1.154 extracted from

Russo, A.; Okur, M.N.; Bosland, M.; OBryan, J.P.
Phosphatidylinositol 3-kinase, class 2 beta (PI3KC2beta) isoform contributes to neuroblastoma tumorigenesis (2015), Cancer Lett., 359, 262-268.

Search for more literature for 2.7.1.154

Protein Variants

Protein Variants	Comment	Organism
additional information	generation of PI3KC2beta-silenced neuroblastoma cell lines	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O00750	gene PIK3C2B	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuroblastoma cell	PI3K class IIbeta (PI3KC2beta) and its regulator intersectin 1 (ITSN1) are highly expressed in primary neuroblastoma tumors and cell lines	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
phosphatidylinositol 3-kinase class 2 beta	-	Homo sapiens
PI3KC2beta	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	PI3KC2beta-silencing inhibits early stages of neuroblastoma tumorigenic growth, but does not alter apoptotic or endocytic pathways, and silencing of the enzyme's regulator intersectin 1, ITSN1, also dramatically reduces the tumorigenic potential of neuroblastoma cells. Overexpression of PI3KC2beta rescues the anchorage-independent growth of ITSN1-silenced cells suggesting that PI3KC2beta mediates ITSN1's function in neuroblastoma cells. Silencing ITSN1 or PI3KC2beta decreases AKT activation in neuroblastoma cells	Homo sapiens
physiological function	phosphatidylinositol 3-kinase class 2 beta isoform, PI3KC2beta, contributes to neuroblastoma tumorigenesis. Activation of the PI3K target AKT is frequent in neuroblastoma and correlates with poor prognosis	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)