Cloned (Comment) | Organism |
---|---|
expression of class IA and class II isozymes in HEK293 cells alter the regulation of protein kinases in response to growth factors as part of signalling cascades, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
LY294002 | - |
Homo sapiens | |
Wortmannin | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the isozymes activate different signalling cascades via stem cell factor SCF in overexpressing cancer cell lines, e.g. association with c-Met, IGF-IR, regulation, class II PI3K C2beta blocks both protein kinase and small lung cell carcinoma in reponse to stem cell factor, polypeptide growth factors induce the recruitment of class IA and II isozymes to phosphotyrosine-containing signalling complexes, detailed overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
8 isozymes, class IA and class II, e.g. class IA p85/p110alpha or class II PI3K C2beta | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | the enzyme is regulated by phosphorylation, involving different kinases and polypeptide growth factors, overview | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
small cell lung cancer cell | different cell lines overexpress different isozymes, e.g. cell lines H-69, HC-33, H-510, H-1045, and H-209 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the isozymes activate different signalling cascades via stem cell factor SCF in overexpressing cancer cell lines, e.g. association with c-Met, IGF-IR, regulation, class II PI3K C2beta blocks both protein kinase and small lung cell carcinoma in reponse to stem cell factor, polypeptide growth factors induce the recruitment of class IA and II isozymes to phosphotyrosine-containing signalling complexes, detailed overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphoinositide 3-kinase | - |
Homo sapiens |