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Literature summary for 2.7.1.154 extracted from
- Mechanisms regulating phosphoinositide 3-kinase signalling in insulin-sensitive tissues (2005), Acta Physiol. Scand., 183, 3-12.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| adipokines | block insulin signalling via PI3K isozymes | Homo sapiens | |
| adipokines | block insulin signalling via PI3K isozymes | Mus musculus | |
| Caffeine | might inhibit the enzyme | Homo sapiens |  |
| Caffeine | might inhibit the enzyme | Mus musculus | |
| cytokines | block insulin signalling via PI3K isozymes | Homo sapiens | |
| cytokines | block insulin signalling via PI3K isozymes | Mus musculus | |
| additional information | enzyme is regulated by several feedback inhibition possibilities in the insulin signalling pathway, overview | Homo sapiens | |
| additional information | enzyme is regulated by several feedback inhibition possibilities in the insulin signalling pathway, overview | Mus musculus | |
| naringenin | might inhibit the enzyme | Homo sapiens | |
| naringenin | might inhibit the enzyme | Mus musculus | |
| Wortmannin | class I isozyme inhibitor, isozyme PI3K-C2alpha is resistant to inhibition | Homo sapiens | |
| Wortmannin | class I isozyme inhibitor, isozyme PI3K-C2alpha is resistant to inhibition | Mus musculus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Mus musculus | |
| Mg2+ | - |
Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 85000 | - |
x * 110000, catalytic subunit, + x * 85000, catalytically inactive adaptor subunit | Mus musculus |
| 85000 | - |
x * 110000, catalytic subunit, + x * 85000, catalytically inactive adaptor subunit | Homo sapiens |
| 110000 | - |
x * 110000, catalytic subunit, + x * 85000, catalytically inactive adaptor subunit | Mus musculus |
| 110000 | - |
x * 110000, catalytic subunit, + x * 85000, catalytically inactive adaptor subunit | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + phosphoinositides | Mus musculus | enzyme plays a role in cellular signalling pathways, e.g. the insulin signalling pathways acting via class Ia and PI3K-C2alpha isozymes synthesizing 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate and affecting the glucose metabolism, the enzyme antagonizes with phosphatases both regulating the signalling pathways together, the enzyme is also involved in insulin resistance in peripheral tissues, overview | ADP + ? | - |
? | |
| ATP + phosphoinositides | Homo sapiens | enzyme plays a role in cellular signalling pathways, e.g. the insulin signalling pathways acting via class Ia and PI3K-C2alpha isozymes synthesizing 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate and affecting the glucose metabolism, the enzyme antagonizes with phosphatases both regulating the signalling pathways together, the enzyme is also involved in insulin resistance in peripheral tissues, overview | ADP + ? | - |
? | |
| ATP + phosphoinositides | Homo sapiens PI3K-C2alpha | enzyme plays a role in cellular signalling pathways, e.g. the insulin signalling pathways acting via class Ia and PI3K-C2alpha isozymes synthesizing 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate and affecting the glucose metabolism, the enzyme antagonizes with phosphatases both regulating the signalling pathways together, the enzyme is also involved in insulin resistance in peripheral tissues, overview | ADP + ? | - |
? | |
| additional information | Mus musculus | enzyme regulation, overview | ? | - |
? | |
| additional information | Homo sapiens | enzyme regulation, overview | ? | - |
? | |
| additional information | Homo sapiens PI3K-C2alpha | enzyme regulation, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O00443 | PI3K-C2alpha | - |
| Homo sapiens PI3K-C2alpha | O00443 | PI3K-C2alpha | - |
| Mus musculus | Q61194 | isozyme PI3K-C2alpha | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | the phosphorylated enzyme is inactive | Mus musculus |
| phosphoprotein | the phosphorylated enzyme is inactive | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + phosphoinositides | enzyme plays a role in cellular signalling pathways, e.g. the insulin signalling pathways acting via class Ia and PI3K-C2alpha isozymes synthesizing 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate and affecting the glucose metabolism, the enzyme antagonizes with phosphatases both regulating the signalling pathways together, the enzyme is also involved in insulin resistance in peripheral tissues, overview | Mus musculus | ADP + ? | - |
? | |
| ATP + phosphoinositides | enzyme plays a role in cellular signalling pathways, e.g. the insulin signalling pathways acting via class Ia and PI3K-C2alpha isozymes synthesizing 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate and affecting the glucose metabolism, the enzyme antagonizes with phosphatases both regulating the signalling pathways together, the enzyme is also involved in insulin resistance in peripheral tissues, overview | Homo sapiens | ADP + ? | - |
? | |
| ATP + phosphoinositides | phosphorylation of the D-3 position on the inositol ring | Mus musculus | ADP + ? | - |
? | |
| ATP + phosphoinositides | phosphorylation of the D-3 position on the inositol ring | Homo sapiens | ADP + ? | - |
? | |
| ATP + phosphoinositides | enzyme plays a role in cellular signalling pathways, e.g. the insulin signalling pathways acting via class Ia and PI3K-C2alpha isozymes synthesizing 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate and affecting the glucose metabolism, the enzyme antagonizes with phosphatases both regulating the signalling pathways together, the enzyme is also involved in insulin resistance in peripheral tissues, overview | Homo sapiens PI3K-C2alpha | ADP + ? | - |
? | |
| ATP + phosphoinositides | phosphorylation of the D-3 position on the inositol ring | Homo sapiens PI3K-C2alpha | ADP + ? | - |
? | |
| additional information | enzyme regulation, overview | Mus musculus | ? | - |
? | |
| additional information | enzyme regulation, overview | Homo sapiens | ? | - |
? | |
| additional information | enzyme regulation, overview | Homo sapiens PI3K-C2alpha | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 110000, catalytic subunit, + x * 85000, catalytically inactive adaptor subunit | Mus musculus |
| ? | x * 110000, catalytic subunit, + x * 85000, catalytically inactive adaptor subunit | Homo sapiens |
| More | domain structure of the adaptor subunit containing a SH3 domain and 2 SH2 domains, three different isozymes of the catalytically subunits P110alpha, P110beta, and P110gamma determine the 3 isozymes alpha, beta, gamma of the enzyme, all P110 subunits can interact with the p85 adaptor subunit | Mus musculus |
| More | domain structure of the adaptor subunit containing a SH3 domain and 2 SH2 domains, three different isozymes of the catalytically subunits P110alpha, P110beta, and P110gamma determine the 3 isozymes alpha, beta, gamma of the enzyme, all P110 subunits can interact with the p85 adaptor subunit | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| class-I PI 3-kinase | - |
Mus musculus |
| class-I PI 3-kinase | - |
Homo sapiens |
| class-II PI 3-kinase | - |
Mus musculus |
| class-II PI 3-kinase | - |
Homo sapiens |
| PI3K-C2alpha | - |
Mus musculus |
| PI3K-C2alpha | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
| ATP | - |
Homo sapiens | |
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