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Literature summary for 2.7.1.154 extracted from

  • Ktori, C.; Shepherd, P.R.; O'Rourke, L.
    TNF-alpha and leptin activate the alpha-isoform of class II phosphoinositide 3-kinase (2003), Biochem. Biophys. Res. Commun., 306, 139-143.
    View publication on PubMed
Search for more literature for 2.7.1.154

Activating Compound

Activating Compound Comment Organism Structure
Insulin
-
 Mus musculus
leptin 4fold activation of class II isoform PI3K-C2beta by activation of the ERK pathway, no recruitment of tyrosine phosphorylated proteins to the isozyme, blockade of activation by MEK-inhibitor PD98059 Mus musculus
additional information TNFalpha and leptin stimulate the alpha-isoform of class II phosphoinositide 3-kinase Mus musculus
TNF-alpha 2.8fold activation of class II isoform PI3K-C2beta by activation of the ERK pathway, blockade of activation by MEK-inhibitor PD98059 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus TNFalpha and leptin stimulate the alpha-isoform of class II phosphoinositide 3-kinase ?
-
 ?
additional information Mus musculus the enzyme is regulated by intracellular signalling mechanisms ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 PI3KC2alpha
-
Mus musculus
-
 class II isoform PI3K-C2beta
-

Source Tissue

Source Tissue Comment Organism Textmining
J774.2 cell
-
 Mus musculus
-
J774.2 cell macrophage Mus musculus
-
macrophage cell culture Mus musculus
-
macrophage cell culture, cell line J774.2 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol preferred substrate of enzyme form PI3K-C2beta Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
 ?
additional information TNFalpha and leptin stimulate the alpha-isoform of class II phosphoinositide 3-kinase Mus musculus ?
-
 ?
additional information the enzyme is regulated by intracellular signalling mechanisms Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
phosphoinositide 3-kinase
-
 Mus musculus
PI 3-kinase
-
 Mus musculus
PI3K
-
 Mus musculus