Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of a mouse model of smooth muscle cellĀspecific p110alpha deficiency. Targeted deletion of p110alpha in sm-p110alpha-/- mice blunts growth factorĀinduced cellular responses and abolishes neointima formation after balloon injury of the carotid artery in mice. p110 Subunit knockdown via specific siRNA application | Mus musculus |
additional information | generation of a mouse model of smooth muscle cellĀspecific p110delta deficiency. Targeted deletion of p110delta doe not affect vascular remodeling in vivo. p110 Subunit knockdown via specific siRNA application | Mus musculus |
additional information | p110 subunit knockdown via specific siRNA application | Rattus norvegicus |
additional information | p110 subunit knockdown via specific siRNA application | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
IC-87114 | p110delta-specific small molecule inhibitor | Homo sapiens | |
IC-87114 | p110delta-specific small molecule inhibitor | Rattus norvegicus | |
PIK-75 | p110alpha-specific small molecule inhibitor | Homo sapiens | |
PIK-75 | p110alpha-specific small molecule inhibitor; p110alpha-specific small molecule inhibitor | Mus musculus | |
PIK-75 | p110alpha-specific small molecule inhibitor | Rattus norvegicus | |
TGX-221 | p110beta-specific small molecule inhibitor | Homo sapiens | |
TGX-221 | p110beta-specific small molecule inhibitor | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Rattus norvegicus | |
Mg2+ | required | Homo sapiens | |
Mg2+ | required | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
85000 | - |
- |
Rattus norvegicus |
85000 | - |
- |
Homo sapiens |
85000 | - |
- |
Mus musculus |
110000 | - |
- |
Rattus norvegicus |
110000 | - |
- |
Homo sapiens |
110000 | - |
- |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | Rattus norvegicus | - |
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate | - |
? | |
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | Homo sapiens | - |
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate | - |
? | |
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | Mus musculus | - |
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00329 | catalytic subunit p110delta; isozyme PI3Kdelta | - |
Homo sapiens | P42336 | catalytic subunit p110alpha; isozyme PI3Kalpha | - |
Homo sapiens | P42338 | catalytic subunit p110beta; isozyme PI3Kbeta | - |
Mus musculus | O35904 | catalytic subunit p110delta; isozyme PI3Kdelta | - |
Mus musculus | P42337 | catalytic subunit p110alpha; isozyme PI3Kalpha | - |
Rattus norvegicus | - |
isozyme PI3Kdelta | - |
Rattus norvegicus | A0A0G2K344 | catalytic subunit p110alpha; isozyme PI3Kalpha | - |
Rattus norvegicus | Q9Z1L0 | catalytic subunit p110beta; isozyme PI3Kbeta | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aortic smooth muscle cell | - |
Rattus norvegicus | - |
coronary artery smooth muscle cell | - |
Homo sapiens | - |
additional information | expression and platelet-derived growth factor beta receptor (betaPDGFR) binding of p110 isoforms in smooth muscle cells (SMCs), overview | Rattus norvegicus | - |
additional information | expression and platelet-derived growth factor beta receptor (betaPDGFR) binding of p110 isoforms in smooth muscle cells (SMCs), overview | Homo sapiens | - |
additional information | expression and platelet-derived growth factor beta receptor (betaPDGFR) binding of p110 isoforms in smooth muscle cells (SMCs), overview | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
Rattus norvegicus | ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate | - |
? | |
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate | - |
? | |
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
Mus musculus | ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
heterodimer | 1 * 110000, subunit p110, + 1 * 85000, subunit p85, class IA PI3K isoforms are heterodimers consisting of a catalytic subunit (p110alpha) and a smaller regulatory subunit (p85) | Mus musculus |
heterodimer | 1 * 110000, subunit p110, + 1 * 85000, subunit p85, class IA PI3K isoforms are heterodimers consisting of a catalytic subunit (p110alpha) and a smaller regulatory subunit (p85) | Homo sapiens |
heterodimer | 1 * 110000, subunit p110, + 1 * 85000, subunit p85, class IA PI3K isoforms are heterodimers consisting of a catalytic subunit (p110alpha) and a smaller regulatory subunit (p85) | Rattus norvegicus |
heterodimer | 1 * 110000, subunit p110, + 1 * 85000, subunit p85, class IA PI3K isoforms are heterodimers consisting of a catalytic subunit (p110beta) and a smaller regulatory subunit (p85) | Homo sapiens |
heterodimer | 1 * 110000, subunit p110, + 1 * 85000, subunit p85, class IA PI3K isoforms are heterodimers consisting of a catalytic subunit (p110beta) and a smaller regulatory subunit (p85) | Rattus norvegicus |
heterodimer | 1 * 110000, subunit p110, + 1 * 85000, subunit p85, class IA PI3K isoforms are heterodimers consisting of a catalytic subunit (p110delta) and a smaller regulatory subunit (p85) | Rattus norvegicus |
heterodimer | 1 * 110000, subunit p110, + 1 * 85000, subunit p85, class IA PI3K isoforms are heterodimers consisting of a catalytic subunit (p110delta) and a smaller regulatory subunit (p85) | Homo sapiens |
heterodimer | 1 * 110000, subunit p110, + 1 * 85000, subunit p85, class IA PI3K isoforms are heterodimers consisting of a catalytic subunit (p110delta) and a smaller regulatory subunit (p85) | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
p110alpha | catalytic subunit | Mus musculus |
p110alpha | catalytic subunit | Homo sapiens |
p110alpha | catalytic subunit | Rattus norvegicus |
p110beta | catalytic subunit | Homo sapiens |
p110beta | catalytic subunit | Rattus norvegicus |
p110delta | catalytic subunit | Rattus norvegicus |
p110delta | catalytic subunit | Homo sapiens |
p110delta | catalytic subunit | Mus musculus |
phosphatidyl-inositol-3-kinase | - |
Rattus norvegicus |
phosphatidyl-inositol-3-kinase | - |
Homo sapiens |
phosphatidyl-inositol-3-kinase | - |
Mus musculus |
phosphatidylinositol 3'-kinase | - |
Rattus norvegicus |
phosphatidylinositol 3'-kinase | - |
Homo sapiens |
phosphatidylinositol 3'-kinase | - |
Mus musculus |
PI3Kalpha | - |
Mus musculus |
PI3Kalpha | - |
Homo sapiens |
PI3Kalpha | - |
Rattus norvegicus |
PI3Kbeta | - |
Homo sapiens |
PI3Kbeta | - |
Rattus norvegicus |
PI3Kdelta | - |
Rattus norvegicus |
PI3Kdelta | - |
Homo sapiens |
PI3Kdelta | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus | |
ATP | - |
Homo sapiens | |
ATP | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | p110delta deficiency did not affect vascular remodeling in vivo | Rattus norvegicus |
malfunction | p110delta deficiency did not affect vascular remodeling in vivo | Mus musculus |
physiological function | class Ia phosphatidylinositol 3-kinase isoform p110alpha is crucial for receptor tyrosine kinases signaling, thus affecting proliferation, migration, and survival of smooth muscle cells, Receptor tyrosine kinasesĀinduced phosphatidylinositol 3'-kinase signaling via the p110alpha isoform plays a central role for vascular remodeling | Mus musculus |
physiological function | class Ia phosphatidylinositol 3-kinase isoform p110alpha is crucial for receptor tyrosine kinases signaling, thus affecting proliferation, migration, and survival of smooth muscle cells, Receptor tyrosine kinasesĀinduced phosphatidylinositol 3'-kinase signaling via the p110alpha isoform plays a central role for vascular remodeling | Homo sapiens |
physiological function | class Ia phosphatidylinositol 3-kinase isoform p110alpha is crucial for receptor tyrosine kinases signaling, thus affecting proliferation, migration, and survival of smooth muscle cells, Receptor tyrosine kinasesĀinduced phosphatidylinositol 3'-kinase signaling via the p110alpha isoform plays a central role for vascular remodeling | Rattus norvegicus |
physiological function | class Ia phosphatidylinositol 3-kinase isoform p110beta is disensible for receptor tyrosine kinases signaling, not affecting proliferation, migration, and survival of smooth muscle cells | Homo sapiens |
physiological function | class Ia phosphatidylinositol 3-kinase isoform p110beta is disensible for receptor tyrosine kinases signaling, not affecting proliferation, migration, and survival of smooth muscle cells | Rattus norvegicus |
physiological function | class Ia phosphatidylinositol 3-kinase isoform p110delta is disensible for receptor tyrosine kinases signaling, p110delta exerts noncatalytic functions in smooth muscle cell proliferation, but had no effect on migration | Rattus norvegicus |
physiological function | class Ia phosphatidylinositol 3-kinase isoform p110delta is disensible for receptor tyrosine kinases signaling, p110delta exerts noncatalytic functions in smooth muscle cell proliferation, but had no effect on migration | Homo sapiens |
physiological function | class Ia phosphatidylinositol 3-kinase isoform p110delta is disensible for receptor tyrosine kinases signaling, p110delta exerts noncatalytic functions in smooth muscle cell proliferation, but had no effect on migration | Mus musculus |